摘要
The title compound （7R,8S,9S,12S）-13,14-dehydro-1-（4-fluorobenzyloxy）-N-methyl- 2,13-dimethoxy-12-hydroxymorphinane was synthesized by the reaction of O-4-bromobenzyl- sinomenine with lithium aluminum hydride. Its chemical structure was determined by X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P1 with Mr = 439.51, a = 7.7236（1）, b = 8.7282（1）, c = 9.9342（2） A, a = 81.176（1）, β = 67.43, γ= 64.577（1）°,μ = 0.76 mm^-1, V= 558.45（2） A3, Z = 1, Dc = 1.307 mg/m3, F（000） = 234 and T= 133 K.
The title compound （7R,8S,9S,12S）-13,14-dehydro-1-（4-fluorobenzyloxy）-N-methyl- 2,13-dimethoxy-12-hydroxymorphinane was synthesized by the reaction of O-4-bromobenzyl- sinomenine with lithium aluminum hydride. Its chemical structure was determined by X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P1 with Mr = 439.51, a = 7.7236（1）, b = 8.7282（1）, c = 9.9342（2） A, a = 81.176（1）, β = 67.43, γ= 64.577（1）°,μ = 0.76 mm^-1, V= 558.45（2） A3, Z = 1, Dc = 1.307 mg/m3, F（000） = 234 and T= 133 K.
基金
supported by the National Natural Science Foundation of China (No.20976017)
Scientific Research Fund of Hunan Provincial Science and Technology Department (No.2009CK3070)
