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胰岛素信号转导通路与骨重建 被引量：2

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摘要 骨是一持续重建的组织。骨重建主要由破骨细胞和成骨细胞参与，以破骨细胞激活和骨吸收开始，以与之相耦联的成骨细胞激活和骨形成终结，贯穿于整个生命过程的始终。破骨细胞和成骨细胞功能受到全身和局部诸多因素调控，除生长激素、雌激素、甲状旁腺激素外，胰岛素信号转导途径相关因子也起着重要作用。本文就胰岛素信号通路对骨重建的作用进行综述。
作者 王燕 李玉坤 刘岩 李宝新
机构地区 河北医科大学第三医院内分泌二科
出处 《中华生物医学工程杂志》 CAS 2011年第2期186-188,共3页 Chinese Journal of Biomedical Engineering
基金 基金项目：河北省自然科学基金（C2009001179） 河北省卫生厅指导课题（20090439）
关键词 胰岛素信号转导通路 骨重建 胰岛素信号转导途径 胰岛素信号通路 甲状旁腺激素 成骨细胞 破骨细胞 细胞激活
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献28

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同被引文献32

  • 1Sajan MP,Standaert ML,Rivas J. Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes,and relationships to hyperlipidaemia and insulin resistance[J].Diabetologia,2009.1197-1207.
  • 2R(a)kel A,Sheehy O,Rahme E. Osteoporosis among patients with type 1 and typc 2 diabctes[J].Diabetes & Metabolism,2008.193-205.
  • 3Sta Romana M,Li-Yu JT. Investigation of the relationship between type 2 diabetes and osteoporosis using bayesian inference[J].Journal of Clinical Densitometry,2007.386-390.
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  • 6Liu R,Bal HS,Desta T. Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation[J].Journal of Dental Research,2006.510-514.
  • 7Fujii H,Hamada Y,Fukagawa M. Bone formation in spontaneously diabetic Torii-newly established model of non-obese type 2 diabetes rats[J].Bone,2008.372-379.
  • 8Kawashima Y,Fritton JC,Yakar S. Type 2 diabetic mice demonstrate slender long bones with increased fragility secondary to increased osteoclastogenesis[J].Bone,2009.648-655.
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中华生物医学工程杂志
2011年 第2期

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