摘要
目的研究人参多糖对创伤脓毒症患者炎症因子及免疫功能的影响,探讨人参多糖在外科感染治疗中的作用。方法 48例创伤脓毒症患者随机分为治疗组24例和对照组24例,对照组采用经典SSC治疗,治疗组在上述治疗基础上加用人参多糖,疗程为7 d。分别观察治疗前和治疗后2组患者相关临床资料和生存分析,比较APACHEⅡ评分,血浆内毒素,肿瘤坏死因子(TNF-α),白细胞介素-6(IL-6),白细胞介素-10(IL-10),CD14+单核细胞HLA-DR,NK细胞和T细胞亚群CD4+、CD8+、CD4+/CD8+百分率的变化。结果治疗组患者机械通气和使用升压药的时间较对照组均明显缩短(P均<0.05);2组APACHEⅡ评分治疗前比较无显著性差异,治疗后第7天时治疗组明显低于对照组(P<0.05)。2组之间28 d病死率比较无显著性差异(P>0.05)。与对照组比较,治疗组内毒素、TNF-α、IL-6水平明显下降,IL-10水平明显升高,CD14+单核细胞HLA-DR,NK细胞和T细胞亚群CD4+、CD8+、CD4+/CD8+均明显上升(P均<0.05)。结论人参多糖可以减轻创伤脓毒症患者的炎症反应,改善其免疫功能,缩短机械通气和使用升压药的时间。
Objective It is to study the influence of ginseng polysaccharide on inflammatory factors and immune function in the patients with posttraumatic sepsis and to approach the role of ginseng polysaccharide in the therapy for surgical infection.Methods Forty-eight patients with posttraumatic sepsis were divided into treatment group and control group in which there were both 24 cases.The control group received classical SSC therapy and the treatment group received classical SSC therapy plus ginseng polysaccharide for seven days.Before and after treatment the clinical data and survival data in the two groups,including the changes of APACHE Ⅱ scores,endotoxin and the percentage of TNF-α,IL-6,IL-10,CD14＋ monocyte HLA-DR,NK cell,CD4＋,CD8＋ and CD4＋/CD8＋,were observed.Results The times of mechanical ventilation and vasopressors used in treatment group were both shorter than that in control group（both P0.05）.The difference in APACHE Ⅱ scores in the two group before treatment was not significant,but the scores in treatment group at the 7th day after treatment was obviously lower than that in control group（P0.05）.The difference in fatality rate at the 28th day after treatment between the two groups was not significant（P0.05）.Compared with control group,the levels of endotoxin,TNF-α and IL-6 decreased obviously and the levels of IL-10,CD14＋ monocyte HLA-DR,NK cell,CD4＋,CD8＋ and CD4＋/CD8＋ heightened obviously（all P0.05）.Conclusion Ginseng polysaccharide can lighten the inflammatory reaction of the patients with posttraumatic sepsis,improve the immunological function and shorten the times of mechanical ventilation and vasopressors used.
出处
《现代中西医结合杂志》
CAS
2011年第23期2866-2868,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
人参多糖
创伤
脓毒症
免疫疗法
ginseng polysaccharide
trauma
sepsis
immunotherapy
