摘要
目的:检测银屑病患者外周血IL-17和IL-22的水平。方法:采用酶联免疫吸附(ELISA)法对40例银屑病患者外周血IL-17和IL-22的水平进行检测。结果:银屑病患者外周血IL-17和IL-22的表达为(18.81±13.80)ng/L和(19.35±17.62)ng/L,均显著高于正常对照组(P<0.01);二者水平与银屑病皮损面积及严重程度指标评分均呈正相关,与患者病程无明显相关性(P>0.05)。结论:IL-17和IL-22在银屑病的发病机制中可能发挥重要作用。
Objective： To determine the expression of interleukin- 17 （IL- 17） and intedeuldn- 22 （IL- 22） in the patients with psoriasis.Methods： The serum levels of 1L- 17 and IL- 22 were measured by competitive enzyme- linked immunoabsorlent assay （ELISA） in 40 patients with psoriasis. Results： The serum levels of IL - 17 and IL- 22 were （ 18.81 ±13.80） ng/L and （ 19.35 ±17.62） ng/L, which were significantly higher in patients with psoriasis than in controls （ P 〈 0.01）. The expression of IL- 17 and IL- 22 was positively associated with the severity of the disease, but there was no association between the expression of IL - 17 and IL - 22 and the duration of the disease （ P 〉 0.05）. Conclusion： IL - 17 and IL - 22 may play an important role in the pathogenesis of psonasis.
出处
《中国麻风皮肤病杂志》
2011年第7期465-467,共3页
China Journal of Leprosy and Skin Diseases
