摘要
目的:通过检测表皮生长因子(EGF)在正常外阴皮肤、外阴上皮内瘤变(VIN)和外阴鳞状细胞癌(VSCC)中的表达,探讨其在外阴癌变中的作用。方法:应用免疫组化SP法进行检测。EGF的表达与外阴肿瘤的临床病理特征相比较。结果:正常外阴组织、低级别VINs、高级别VINs、外阴癌中EGF蛋白阳性表达率分别为0(0/20)、18.2%(2/11)、82.8%(9/11)、100%(60/60),P<0.05。在高、中、低分化的浸润性外阴癌中,EGF的细胞阳性表达率分别为36.2%、42.7%、47.1%,P>0.05。有淋巴结转移者EGF蛋白阳性表达率为30.2%明显低于无淋巴结转移者的49.8%。结论:EGF蛋白的异常表达在外阴癌的发生发展中起着重要的作用,而且可为外阴癌的预后提供重要的信息。
Objective：To study the role of epidermal growth factor（EGF）in vulvar carcinogenesis by determining the expression in normal vulvas and vulvar intraepithelial neoplasia（VIN）and vulvar squamous cell carcinomas（VSCC）.Methods：The immunohistochemistry SP method was used.The expressions of EGF were analyzed with clinical-pathologic featuers of vulvar tumors.Results：The positive rates of expression of FHIT protein in the squamous epithelium of normal vulvas,VINI-II,VINIII and noninvasive carcinoma and invasive vulvar carcinoma were 0（0/20）、18.2%（2/11）、82.8%（9/11）、100%（60/60）,respectively（P0.05）。The rate of the EGF protein expression in the invasive vulva carcinoma with lymphnode metastasis（30.2%）was lower than that without lymphnode metastasis（49.8%）.Conclusion：Abnormal EGF expression may play an important role in the progression of vulvar carcinoma.Furthermore,the expression of EGF may provide important information for the prognosis of vulva carcinoma.
