摘要
目的检测中国汉族人群特异TLR2基因多态性，并分析与结核病易感性之间关系。方法在小样本中测序检测TLR2基因中可能存在的基因多态性，再用连接酶特异检测技术在大样本进行SNP分型，并通过统计学方法分析基因多念件与结核病易感性之间相关性。结果共检测到6个基因多态性，它们在结核病患者与健康人之间等位基因、基因型以及单雕体型上差异无统计学意义（P〉0．05）。结论TLR2基因多态性并不是中国汉族人群结核病发病的重要危险因素。
Objective To study the relationship between toll-like receptor 2 （TLR2） gene polymorphisms and susceptibility to pulmonary tuberculosis in Chinese Hart population. Methods TLR2 gene polymorphisms were analyzed by DNA sequencing in a small amount of samples. SNPs in TLR2 gene were detected by ligase detection technique in a large amount of samples. The relationship between TLR2 gene polymorphisms and susceptibility to pulmonary tuberculosis were analyzed by statistic methods. Results Six gene polymorphisms were found, but there were no significant differences between pulmonary tuberculosis patients and healthy controls by allelic and genotypic analysis （P〉0.05）. Conclusions TLR2 gene polymorphisms are not risk factors for susceptibility to pulmonary TB in Chinese Han population.
出处
《结核病与胸部肿瘤》
2011年第2期79-82,共4页
Tuberculosis and Thoracic Tumor
关键词
结核
肺
TOLL样受体2
多态现象
遗传
疾病遗传易感性
汉族
Tuberculosis, pulmonary
Toll-like receptor 2
Polymorphismgenetic
Genetic predisposition to disease
Han nationality
