摘要
以乙二醇为溶剂,邻氟苯丙酮与水合肼环化生成3-乙基-1-H-吲唑(1),进一步经硝化、还原在吲唑环5位引入氨基得到3-乙基-5-氨基1-H-吲唑(3),化合物3与芳香醛的缩合产物席夫碱4a～4k可与亚磷酸酯5m或5n发生进一步亲核加成制得一系列新型5-氨基-3-乙基-1H-吲唑的α-氨基膦酸酯类衍生物6ma～6mk与6na～6nk,所得新化合物均经1H NMR,13C NMR,31P NMR,IR,MS和HRMS确证结构.
A series of novel 1H-indazole derivatives 6ma--6mk and 6na-6nk were synthesized via the nucleophilic addition reaction of phosphate esters 5m or 5n with Schiff bases 4a--4k, which were synthesized from nitration, reduction and condensation of aromatic aldehyde by using the 3-ethyl-1H-indazole （1） as starting material. The structures of new compounds were characterized by 1H NMR, 13C NMR, 31p NMR, IR, MS and HRMS spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2011年第7期1011-1019,共9页
Chinese Journal of Organic Chemistry
