摘要
目的:确定livin和cleaved caspase-3在尖锐湿疣(condyloma acuminatum,CA)组织中的表达及意义。方法:采用免疫组化SP法检测livin和cleaved caspase-3在34例CA组织和15例正常皮肤组织中的表达。结果:正常皮肤中livin与cleaved caspase-3均无表达,CA组织中二者表达的阳性率分别为82.4%和38.2%;两种蛋白在CA组织中的表达呈负相关(r=-5.25,P<0.001)。结论:Livin抑制caspase-3的激活,两者共同参与CA的发病过程,可能与CA的发生、发展相关。
Objective： To investigate the expression and significance of livin and cleaved caspase- 3 in condyloma acuminatum （CA） Method： The immunohistochemical SP method was applied to detect the expression of livin and cleaved caspase - 3 in 34 cases of CA and 15 normal skin controls. Results： The positive expression rates were 82.4% for livin and 38.2% for cleaved caspase - 3 in CA, both were significantly higher than that in normal skin （ P 〈 0.01 ）, where the expressions of the two proteins were both negative. The expression of livin and cleaved caspase - 3 was negatively correlated each other in CA （ r = - 5.25, P 〈 0.01）. Conclusion： livin may promote the development of CA by inhibiting the activation of caspase - 3. Both of livin and cleaved caspase - 3 may participate in the pathogenesis of CA.
出处
《中国麻风皮肤病杂志》
2011年第6期394-397,共4页
China Journal of Leprosy and Skin Diseases
