摘要
目的:探讨Toll样受体(TLR)4和在非小细胞肺癌组织中的表达及其与临床病理参数之间的相关性。方法:RT-PCR和Western blot法检测TLR4在mRNA和蛋白水平的表达情况。结果:非小细胞肺癌组织中TLR4的表达高于癌旁正常组织。并且肿瘤细胞的分化程度与TLR4的表达水平呈正相关,而TLR4表达与患者的年龄、性别、吸烟情况、肿瘤组织学类型、淋巴结转移和肿瘤远处转移并没有相关性。结论:TLR4在肺癌组织中表达上调,表明其可能参与了肺癌的发生发展,为恶性肿瘤的治疗提供一种潜在的方法。
Objective：To investigate the expressions of Toll-like receptors（TLR） 4 in non-small-cell lung cancer（NSCLC） and the association of the expressions with the clinical and pathological features.Methods：mRNA and protein expressions of TLR4 was detected by RT-PCR and Western blot.Results：The expressions of TLR4 were higher in the cancer tissue than in the normal paracancerous tissue and not related with age,sex,smoking,histological type of tumor,and TNM staging.However,TLR4 expression was positively related with the degree of cell differentiation.Conclusions：Both mRNA and protein expressions of TLR4 are upregulated in NSCLC tissue,suggesting that TLR4 may be involved in the oncogenesis and development of NSCLC.
出处
《航空航天医学杂志》
2011年第7期815-816,893,共3页
Journal of Aerospace medicine
