摘要
目的观察血液透析或血液滤过治疗急性重度酒精中毒的临床疗效。方法将65例急性重度酒精中毒患者随机分为3组:一般治疗组(21例)仅予以纳洛酮等一般治疗,血液透析组(25例)在一般治疗的基础上予以血液透析治疗,血液滤过组(19例)在一般治疗的基础上予以血液滤过治疗。比较3组患者在治疗过程中的意识恢复时间、并发症发生情况、死亡率、炎症因子IL-6、TNF-α的变化等。结果血液透析组与血液滤过组两组间患者在治疗效果、死亡率等差异均无统计学意义(P>0.05)。血液透析组与血液滤过组两组间患者在并发症的发生情况差异有统计学意义(P<0.05)。血液透析组或血液滤过组与一般治疗组两组间患者的治疗效果、死亡率、并发症发生情况等差异均有统计学意义(P<0.05)。结论应用血液透析或血液滤过救治急性重度酒精中毒,可明显缩短患者意识恢复时间,减少并发症,减轻炎症反应,疗效明显优于应用纳洛酮等一般治疗者,但对于血流动力学不稳定者血液滤过优于血液透析。
Objective To study the therapeutic effect of hemodialysis treatment or Hemofiltration Treatment on acute severe alcoholism.Methods 65 patients with acute severe alcoholism were divided into 3 groups.Group 1：Traditional Treatment（21 cases）：traditional treatment with naloxone.Group 2：Hemodialysis Treatment（25 cases）：traditional treatment with hemodialysis.Group 3：Hemofiltration Treatment（19 cases）：traditional treatment with hemofiltration.Then compare the therapeutic effect on the average time of consciousness recovery,complicating disease,mortality rate and the expressions of IL-6 and TNF-α between pre-treatment and post-treatment on the these three groups.Results The differences of therapeutic effect,mortality rate between Hemodialysis Treatment and Hemofiltration Treatment had no statistically significance（P0.05）.The differences of rate of complicating disease between Hemodialysis Treatment and Hemofiltration Treatment have statistically significance.（P0.05）.The differences of therapeutic effect,mortality rate and rate of complicating disease on Hemodialysis Treatment or Hemofiltration Treatment and Traditional Treatment have statistically significance.（P0.05）.Conclusion Apply Hemodialysis or Hemofiltration can shorten patients consciousness recovery time,alleviate inflammation,reduce complications and its therapeutic effect is superior to alone-used naloxone.But for Hemodynamics unstable patients Hemofiltration is superior to Hemodialysis.
出处
《成都医学院学报》
CAS
2011年第2期144-147,共4页
Journal of Chengdu Medical College
关键词
血液透析
血液滤过
酒精中毒
疗效
Hemodiafiltration
Hemofiltration
Alcoholism
Effect
