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肿瘤血管内皮细胞对胶质瘤细胞侵袭力的影响 被引量：5

Effects of vascular endothelial cell on invasive properties of glioma cells
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摘要 目的探讨胶质瘤血管内皮细胞(GVEC)在胶质瘤瘤细胞浸润过程中的作用。方法通过免疫磁珠分离肿瘤血管内皮细胞,Tanswell研究内皮细胞对胶质瘤细胞的迁徙和侵袭能力。结果将内皮细胞与胶质瘤细胞共同培养后能显著增加其迁徙和侵袭能力,并能增加MMP-2,9蛋白的表达。结论血管内皮细胞与胶质瘤浸润的过程密切相关,通过增加MMP-2,9蛋白的表达提高浸润的能力。 Objective To explore the effect of glioma vascular endothelial cells （ GVEC ） on the invasive properties of glioma ceils. Methods Vascular endothelial cell were selected with MACS beads, migratory and invasiveness of glioma cells was analyzed in matrigel matrix, in vitro. Resluts Co-culture of vascular endothelial cells and glioma cells could enhance their migratory and invasiveness each other,and increase the experssions of MMP-2,9. Conclusion Vascular endothelial cells could enhance the invasive ability of the glioma cells by induced the experssion of MMP-2,9.
作者 韩易 苏贺先 马骏 李健 孙涛
机构地区 蚌埠医学院第一附属医院神经外科
出处 《临床神经外科杂志》 CAS 2011年第3期139-141,共3页 Journal of Clinical Neurosurgery
基金 蚌埠医学院科研基金(BY0721)
关键词 胶质瘤 血管内皮细胞 迁移 侵袭 glioma vascular endothelial cell migration invasion
分类号 R730.5 [医药卫生—肿瘤]
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参考文献6

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同被引文献21

  • 1魏尔清.半胱氨酰白三烯受体调节脑内炎症病变的研究展望[J].浙江大学学报（医学版）,2011,40(2):117-122. 被引量：5
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  • 10Ridgway John,Zhang Gu,Wu Yan,Stawicki Scott,Liang Wei-Ching,Chanthery Yvan,Kowalski Joe,Watts Ryan J,Callahan Christopher,Kasman Ian,Singh Mallika,Chien May,Tan Christine,Hongo Jo-Anne S,de Sauvage Fred,Plowman Greg,Yan Minhong.Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature . 2006

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临床神经外科杂志
2011年 第3期

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