摘要
运用文献资料等方法,对运动与骨组织TGF-β/Smads的关系进行探析。结果表明:转化生长因子-β是骨组织中含量最丰富的细胞调节因子之一,是一族具有多种功能的蛋白多肽,Smads是TGF-β特异的细胞内信号转导分子,可介导TGF-β与靶基因间的信息传递过程。TGF-β/Smads信号转导通路具有促进成骨细胞增殖与分化、刺激骨形成的作用。通过运动提高其含量,会影响骨代谢的进程,这将在防治骨质疏松及解决骨健康相关问题中发挥重要的作用。
By using the methods of documents,this article analyses the relationship between sports and TGF-β/Smads.The results show that transforming growth factor beta is the one of the most abundant of cytokines in bone tissue and is a multi-peptide gene with various functions.Smad is specific intracellular mediators that transduce TGF-β aignal.TGF-β/Smads signal transduction pathway can promotes the proliferation and differentiation of osteoblasts and stimulates bone formation action.The expression of TGF-β/Smads improved by sports can affect bone metabolism process.The researches will play an important role in preventing osteoporosis and solving bone health related problems.
出处
《山西师大体育学院学报》
2011年第3期115-119,共5页
Journal of Physical Education Institute of Shanxi Teachers University
