摘要
目的研究局部晚期乳腺癌改良根治术后大分割放疗与常规分割放疗的疗效、副反应。方法 100例局部晚期乳腺癌病例,病人均接受乳腺癌改良根治术和术后6~8周期化疗,随机分为大分割放疗和常规分割放疗2组：大分割放射治疗组2.9 Gy/次,每周5次,总剂量43.5 Gy;常规分割治疗组2 Gy/次,每周5次,总剂量50 Gy。结果大分割放射治疗组和常规分割放射治疗组的3年总生存率分别为82.4%和85.7%,局部区域复发率分别为7.8%和6.1%,急性2~3级放射性皮肤损伤发生率分别为7.8%和6.1%（P〉0.05）,两组均无严重的后期反应发生（臂丛损伤、皮肤溃疡形成、放射性肺炎等）,心电图所示两组心肌缺血性改变也无明显差别。结论大分割放射治疗缩短了治疗时间,其总生存率及局部复发率、疗后毒副作用与常规分割放射治疗无明显差异,可作为局部晚期乳腺癌改良根治术后常规辅助放疗的替代放疗方案。
Objective To study the effect and toxicity of post-mastectomy radiotherapy with different fractionated dose schemes for local advanced breast cancer.Methods A total of 100 patients with local advanced breast cancer,who received mastectomy and 6~8 cycles of chemotherapy after the surgery,were randomized to hypofractionation group and conventional fractionation group.The hypofractionation group received 43.5Gy（2.9 Gy per fraction and five fraction per week）;the conventional group received 50 Gy（2.0 Gy per fraction and five fraction per week）.Results The 3-year overall survival rate was 82.4% and 85.7% in each group respectively（P0.05）.The local relapse rate was 7.8% and 6.1%（P0.05）.The rate of grade 2 and 3 acute skin toxicity was 7.8% and 6.1%,respectively（P0.05）.No severe toxicity,including brachial plexus injury,skin ulcer,radiation pneumonitis,was found in both groups.ECG did not show any change of myocardial ischemia in both groups.Conclusion Hypofractionated radiotherapy can shorten the time of treatment,while it has the same overall rate,local relapse rate and toxicity as conventional radiation,which could be used as an alternative of the conventional radiation in patients with local advanced breast cancer.
出处
《实用临床医药杂志》
CAS
2011年第13期21-23,共3页
Journal of Clinical Medicine in Practice
关键词
乳腺癌
改良根治术
大分割放疗
预后
副反应
breast carcinoma
modified mastectomy
hypofractionation
prognosis
toxicity
