摘要
目的评价左旋布比卡因用于胸段硬膜外麻醉的临床镇痛效果和安全性。方法选择78例美国麻醉医师协会(ASA)分级1～2级、硬膜外麻醉下行乳房整形手术的患者,随机均分为3组。A组用0.5%左旋布比卡因,B组用0.5%罗哌卡因,C组用0.5%布比卡因,硬膜外注入,记录镇痛起效时间、镇痛持续时间,运动阻滞、术中镇痛效果和不良反应。结果与C组比较,A组、B组镇痛起效时间短、维持时间长(P<0.05);B组运动阻滞弱(P<0.05);A组、B组呼吸困难发生率少于C组(P<0.05),其他低血压、恶心呕吐等不良反应发生率相当。结论 0.5%左旋布比卡因用于胸段硬膜外麻醉安全、有效。
Objective To evaluate levobupivacaine′s clinical analgesic effect and safety in thoracic epidural anesthesia.Methods Seventy-eight patients undergoing breast plastic surgery,ASA Ⅰ-Ⅱ,were enrolled in the study and randomly divided into three groups.Group A received 0.5%levobupivacaine,group B received 0.5%ropivacaine and group C received 0.5%bupivacaine by epidural injection.And the analgesic onset time,duration,motor block,analgesic quality and adverse reactions were recorded.Results Compared with group C,Group A and B took effect in short time and lasted a long time（P 0.05）;group B had weak motor block（P 0.05）;group A and B had the lower incidence of dyspnoea than group C（P 0.05）.And there were no significant differences among the three groups in the incidence of hypotension and nausea.Conclusion 0.5%levobupivacaine is safe and effective in thoracic epidural anesthesia.
出处
《中国药业》
CAS
2011年第14期28-29,共2页
China Pharmaceuticals
