摘要
目的探讨米索前列醇不同给药途径预防产后出血的临床效果。方法 224例可能发生产后出血的产妇被随机分为观察组和对照组,两组均给予缩宫素,观察组通过直肠给药给予米索前列醇,对照组通过阴道给药给予米索前列醇。结果两组均未发生休克症状,观察组2h出血量、24h出血量以及产后出血率方面均显著少于对照组(P<0.05或P<0.01),两组舒张压、收缩压和药物反应无显著统计学差异(P>0.05)。结论通过直肠途径给予米索前列醇预防产后出血,在保证安全性的同时,能显著提高临床效果,值得临床考虑。
Objective To explore theclinical effect of misoprostol used in prevention of postpartum hemorrhage throughout different routes of drug-reception.Methods 224 cases of patients with possibility of postpartum hemorrhage were randomly divided into observation group and control group.Both groups were given oxytocin,observation group were given misoprostol throughout rectal administration,and control group throughout intravaginal administration.Results There was no case of shock happened,The amount of bleeding in 2 and 24 hours,and rate of postpartum hemorrhage in observation group were significantly less than that in control group（P 0.05 or P 0.01）.The SBP,DBP and side-reaction in two groups had no significant difference（P 0.05）.Conclusion Misoprostol throughout rectal administration used in prevention of vaginal delivery,can significantly enhance clinical effect on base of guaranteeing the safety,so it deserved considering in clinical work.
出处
《中国医药指南》
2011年第19期217-218,共2页
Guide of China Medicine
关键词
产后出血
缩宫素
米索前列醇
直肠给药
Postpartum hemorrhage
Oxytocin
Misoprostol
Rectal administration
