摘要
目的：研究重组白细胞介素２（ｒＩＬ－ ２） 对下丘脑－ 垂体－ 肾上腺轴的作用。方法：采用ｒＩＬ－ ２ 静脉注入（Ｂ组注入前用抗－ ＣＲＨ 血清预处理） ，测定注入ｒＩＬ－ ２ 后不同时间ＣＲＨ，ＡＣＴＨ 及ＣＯＲＴ 血浆含量变化。结果：ｒＩＬ－ ２ 可使不同水平的ＣＲＨ，ＡＣＴＨ，ＣＯＲＴ 血浆含量升高（Ａ 组）（ Ｐ＜ ０－０１） ，当预先注入抗－ ＣＲＨ 血清后ＡＣＴＨ、ＣＯＲＴ 的升高不被阻断（Ｂ 组） 。结论：ｒＩＬ－ ２ 对ＨＰＡＡ 的激活作用不是通过ＣＲＨ
AIM and METHODS: In order to clarify the mechanism which interleukin-2(IL-2) activated the hypothalamic-pituitary-adrenal axis (HPAA) in mice, adopted iv administration of rIL-2 [B group before inject by the pretreatment was pretreated with coticotropin-releasing-hormone(CRH) antiserum], followed rIL-2 iv injected 10 min later at variation time concentration of CRH, adrenocorticotropic hormone (ACTH) and corticosterone (CORT) in the plasma were determined. RESULTS:Level of CRH, ACTH and CORT of A group by rIL-2 induced got to peak in time 120 min( P<0.01 ), but ACTH and CORT of B group response to rIL-2 was not blocked by the pretreatment with CRH antiserum. CONCLUSION:The rIL-2 activation HPAA should not be mediated by endogenous CRH.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第11期1021-1023,共3页
Chinese Journal of Pathophysiology
