摘要
目的观察应用大剂量静脉用丙种球蛋白(IV IG),对病毒性脑膜炎的治疗效果。方法将收治的269例病毒性脑膜炎患儿,随机分为治疗组130例和对照组139例,对照组给予降颅压、对症支持治疗和病毒唑、干扰素等常规治疗,治疗组则在此基础上静脉注射IV IG 200～400 mg/(kg.d)3 d,比较2组7、10、15 d治愈率及症状的恢复时间。结果治疗组71、0 d治愈率分别为48.5%、91.5%,显著高于对照组(P<0.05);治疗组15 d治愈率为98.5%,与对照组比较差异无统计学意义。结论大剂量静脉注射IV IG治疗病毒性脑膜炎效果明显。
OBJECTIVE To investigate the efficacy of high-dose intravenous immunoglobulin （IVIG） in treatment of viral meningitis. METHODS A total of 269 patients with viral meningitis were randomly divided into treatment group （130 cases） and control group （139 cases）. The control group received lower intracranial pressure, symptomatic and supportive treatment and conventional therapy such as ribavirin, interferon. Treatment group were added to IV IG （200-400mg·kg^-1·d^-1） 3days on this basis. Compared two groups seven days,ten days and fifteen days cure rate and recovery time of clinical symptoms. RESULTS The cure rates of treatment group for 7d and 10 d were 48.5%, 91.5%, respectively, which were significantly higher than that in control group （P〈 0.05）. The cure rate of treatment group for 15d was 98. 5%, the difference was not statistically significant. CONCLUSION Viral meningitis can be treated with high dose intravenous IV IG.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第14期2960-2961,共2页
Chinese Journal of Nosocomiology
关键词
丙种球蛋白
静脉注射
病毒性脑膜炎
Gamma globulin
Intravenous injection
Viral meningitis
