摘要
目的：制备盐酸万古霉素的缓释微粒给药系统。方法：以生物相容性好的壳聚糖为载体材料,采用离子交联法制备盐酸万古霉素的壳聚糖纳米粒,通过喷雾干燥法将纳米胶体液进一步制成纳米粒-微粒粉末,并考察其体外缓释特性。结果：离子交联法制备壳聚糖纳米粒简便、易行,喷雾干燥制得的微粒外观圆整,粒径为1~3μm。盐酸万古霉素微粒的载药量为（9.25±1.36）%,12 h的体外累积释药百分数为55.93%,96 h时达到85%。结论：盐酸万古霉素的壳聚糖纳米粒-微粒系统具有明显的缓释效应。
Objective：To prepare vancomycin hydrochloride loaded sustained-release microparticles delivery system.Methods： Vancomycin hydrochloride loaded nanoparticles was formed through ionotropic gelation process with biocompatible chitosan as the carrier material.Then a one-step technique of spray drying was used to microencapsulate the colloidal nanoparticle suspension to form powdered nanoparticles-in-microparticles system directly.The drug release property was investigated in vitro.Results： The chitosan nanoparticles could be prepared without organic solvent.The diameters of the spray-dried microparticles with general spherical appearance ranged between 1-3 μm.The resulting nanoparticles-in-microparticles system achieved（9.25±1.36）% of drug-loading capacity.The cumulative drug release was 55.93% within 12 h,and about 85% of drug could be released from the microparticles after 96 h.Conclusion： The assembled vancomycin hydrochloride loaded nanoparticles-in-microparticles system has good sustained-release property.
出处
《药学服务与研究》
CAS
CSCD
2011年第3期180-182,共3页
Pharmaceutical Care and Research
基金
国家自然科学基金资助项目(No.30973661)
上海市纳米技术专项基金资助项目(No.0852nm04300)
关键词
盐酸万古霉素
壳聚糖
纳米粒-微粒
离子交联法
喷雾干燥
vancomycin hydrochloride
chitosan
nanoparticles-in-microparticles
ionotropic gelation process
spray drying
