期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

分子伴侣Tapasin在介导免疫反应中的作用

The role of molecular chaperone Tapasin in immune response
原文传递
导出
摘要 分子伴侣Tapasin是抗原提呈相关转运蛋白的基因产物，和MHC—Ⅰ同为免疫球蛋白超家族的成员，与MHC分子和多肽装配密切相关，是MHC—Ⅰ类分子与TAP之间的桥梁。Tapasin在抗原提呈过程中有着重要作用，因而了解其生物学特征、在介导免疫反应中的作用及与疾病的相关性具有重要意义。 The molecular chaperone Tapasin is a transporter gene product associated with antigen processing（TAP） , and it is also the member of immunoglobulin superfamily as MHC- Ⅰ . Tapasin bridges MHC- Ⅰ and TAP, and it plays an important role in the process of antigen presenting. In this review, we mainly described its biological characteristics, its role in mediating immune responses and its correlation with diseases.
作者 刘红红 陈小华 汤正好
机构地区 上海交通大学附属第六人民医院感染科
出处 《国际免疫学杂志》 CAS 北大核心 2011年第4期262-264,共3页 International Journal of Immunology
基金 国家自然科学基金资助项目（31000414）
关键词 TAPASIN MHC—Ⅰ类分子 抗原提呈 免疫反应 Tapasin MHC-Ⅰ Antigen presenting Immune response
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献21

  • 1Li S , Paulsson KM, Chen W, et al. Tapasin is required for effi- cient pep2 tide binding to transporter associated with antigen pro- cessing. Biol Chem, 2000 , 275 (3) :1581.
  • 2Pamer E, Cresswell P. Mechanisms of MHC class I-restricted anti- gen processing. Annu Rev Immunol, 1998, 16:323-358.
  • 3Park B, Lee S, Kim E, et al. Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Cell, 2006, 127(2) :249-251.
  • 4Crbrera CM. The double role of the endoplasmic reticulum chaper- one tapasin in peptide optimization of HLA class I molecules. Scand J Immunol, 2007, 65(6) :487-493.
  • 5Chapman DC, Williams DB. ER quality control in the biogenesis of MHC class I molecules. Semin Ceil Dev Biol, 2010, 21 (5): 512-519.
  • 6Lu X, Kavanagh DG, Hill AB. Cellular and molecular require- ments for association of the murlne cytomegalovirus protein m4/ gp34 with major histecompatibility complex class I molecules. J Viral, 2006, 80(12) :6048-6055.
  • 7Lehner PJ, Surman M J, Cresswell P. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line 220. Immunity, 1998, 8:221-231.
  • 8Momburg F, Tan P. Tapasin-the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endo- plasmic reticulum. Mol Immunol, 2002, 39(3-4) :217-233.
  • 9Sadegh-Nassefi S, Chen M, Narayan K, et al. The convergent roles of tapasin and HLA-DM in antigen presentation. Trends Im- munol, 2008, 29(3):141-147.
  • 10Howarth M, Williams A, Tolstrup AB. Tapasin enhances MHC class I peptide presentation according to peptide half-life. Proc Natl Sci USA, 2004, 101 (32) : 11737-11742.

二级参考文献9

  • 1Scung S, Urban JL, Scheiber H. A tumor escape variant that has lost one major histocompatibility complex class Ⅰ restriction element induces specific CD8+T cells to an antigen that no longer serves as a target [J].J Exp Med,1993, 177: 178-933.
  • 2Solheim JC,Carreno BM,Hansen TH.Are transporter associated with antigen processing (TAP) and tapasin class Ⅰ MHC chaperones? [J]. J Immunol, 1997,158:541-543.
  • 3Fromowitz. Ras p21 expression in the progression of breast cancer[J].Human Pathol, 1987, 18: 1268-1275.
  • 4Hicklin DJ, Marincola FM, Ferrone S. HLA class Ⅰ antigen downregulation in human cancer: T-cell immunotherapy revives an old story[J].J Mol med today, 1999, 5: 178-186.
  • 5Garrido F, Ruiz-Cabello F, Cabrera T, et al. Implications for immunosurveillance of altered HLA claass I phenotypes in human tumours[J]. J Immunol Today, 1997, 18:89-95.
  • 6Krishnakumar S, Sundaram A, Abhyankar D,et al. Major histocompatibility antigens and antigen-processing in retinoblastoma[J]. Cancer,2004,100:1059-1069.
  • 7Lehner PJ, Surman, M J, Cresswell P. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line 220[J]. Immunity, 1998, 8:221-231.
  • 8Seliger B, Schreiber K, Delp K, et al. Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines[J].Tissue Antigens, 2001 ,57:39-45.
  • 9Dissemond J, Kothen T, Mors J,et al. Downregulation of tapasin expression in progressive human malignant melanoma[J].Arch Dermatol Res, 2003,295:43-49.

共引文献3

国际免疫学杂志
2011年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部