摘要
目的观察膀胱灌注吡柔比星(THP)/羟喜树碱(HCPT)预防浅表性膀胱癌术后复发和并发症的疗效。方法 62例浅表性膀胱癌术后患者,随机分为两组:Ⅰ组THP(32例),Ⅱ组HCPT(30例),所有病例分别于术后6h(TURBT)和1周(膀胱部分切除术和TURBT合并膀胱穿孔者)开始规律膀胱灌注化疗,比较膀胱癌复发率、并发症及单次费用。结果随访24个月,Ⅰ组和Ⅱ组2年复发率分别为21.87%和26.67%,两组比较差异无统计学意义(P>0.05);化疗不良反应发生率分别为34.37%和20.00%,两组比较差异无统计学意义(P>0.05);单次费用Ⅰ组高于Ⅱ组(P<0.05)。结论 THP、HCPT膀胱灌注均能有效预防浅表性膀胱癌术后复发,操作简单,疗效明显,只是HCPT更具有价格优势。
Objective To observe the efficacy and complications of Pirarubicin（THP）and Hydroxycamptothecin（HCPT）intravesical chemotherapy to prevent recurrence of postoperative superficial bladder cancer.Methods 62 cases of bladder cancer were randomly divided into two groups：Ⅰgroup of THP（32 cases）,Ⅱ group of HCPT（30 cases）.After 6 hours（TURBT）and 1 week（Partial cystectomy and TURBT with vesical perforation）,postoperation regular chemotherapy of bladder was performed with THP and HCPT.We compare the bladder cancer recurrence rate,chemotherapy complications and cost of a single treatment.Results After 24 months＇ follow-up,the recurrence rate of groupⅠand groupⅡ was 21.87% and 26.67%.No statistical difference was seen between the two groups（P〉0.05）.The chemotherapy adverse reaction rate was 34.37% and 20.00%,and there was no statistically difference between the two groups（P〉0.05）.The cost of a single treatment of groupⅠis higher than groupⅡ（P〈0.05）.Conclusions Both THP and HCPT intravesical chemotherapy are effective in preventing recurrence of superficial bladder cancer.Both of them are simple and therapeutic effective,but HCPT is cheaper than THP.
出处
《现代泌尿生殖肿瘤杂志》
2011年第3期154-156,共3页
Journal of Contemporary Urologic and Reproductive Oncology
关键词
膀胱肿瘤
化学疗法
肿瘤
局部灌注
吡柔比星
羟喜树碱
Urinary bladder neoplasms
Chemotherapy
cancer
regional perfusion
Pirarubicin
Hydroxycamptothecin
