摘要
目的 研究双次自体外周血造血干细胞移植治疗急性髓系白血病的临床疗效.方法 对该科2003年4月至2008年12月收治的42例急性髓系白血病患者行自体外周血造血干细胞移植.其中22例急性髓系白血病患者在完全缓解后行第1次自体外周血造血干细胞移植,另外20例急性髓系白血病患者在完全缓解后行第1次自体外周血造血干细胞移植后,3~4个月行第2次自体外周血造血干细胞移植.结果 42例患者均造血功能重建.其中双次自体造血干细胞移植无病生存13例（65%）,复发7例（35%）.单次自体移植无病生存10例（45.5%）,复发12例（54.5%）.结论 双次自体移植较单次自体移植复发率低,移植相关死亡率低,无病生存率较高,可以作为没有找到合适供者或经费困难患者的较好选择.
Objective To study the therapeutic effect of twice autologous peripheral blood stem cell transplantation （auto-PB SCT） in the treatment of patients with acute myeloid leukemia（AML）. Methods Auto PBSCT were performed in 42 cases with AML during Apr 2003 and Dec 2008, including 22 cases, receiving auto-PBSCT for the first time after complete remission, and 20 cases,receiving the second time of auto-PBSCT 3--4 months after the first time of auto-PBSCT after complete remission. Results All of the 42 patients acquired hematopoietic reconstruction. The disease-free survival rates of twice and single auto PBSCT were 65 % and 45.5% respectively,and the relapse rates of twice and once auto-PBSCT were 35 % and 54.5%, respectively. Conclusion Compared with once auto-PBSCT,twice auto-PBSCT might have lower relapse rate,lower transplant-related mortality and higher disease free survival rate, which could be a suitable selection for the treatment of patients without sufficient fund and/or without fit ting donors.
出处
《国际检验医学杂志》
CAS
2011年第11期1159-1159,1162,共2页
International Journal of Laboratory Medicine
关键词
白血病
髓样
急性
造血干细胞移植
双次移植
leukemia,myeloid,acute
hematopoietic stem cell transplantation
double transplantation
