摘要
[目的]探讨胰腺癌生存期可能的影响因素。[方法]回顾123例胰腺癌手术病例,采用Log-Rank及Cox多因素分析生存期的影响因素。[结果]123例患者中位达进展时间(TTP)7.0个月,中位生存期(OS)11.6个月。分层分析提示Ⅰ/Ⅱ期患者的中位TTP(13.0个月)及中位OS(24.3个月)长于Ⅲ/Ⅳ期患者,Ⅲ期患者的中位TTP(5.0个月)及中位OS(10.1个月)长于Ⅳ期患者(2.5个月,3.9个月;P<0.001)。接受根治性手术治疗的患者中位TTP(11.3个月)及中位OS(15.6个月)长于未能切除原发肿瘤的患者(包括短路手术及穿刺)(P<0.01),而接受姑息性短路手术与诊断性穿刺相比,中位TTP(5个月vs.4.8个月)及中位OS(10.1个月vs.7.8个月)差异无统计学意义。术后接受辅助治疗的患者中位TTP(12.8个月)及中位OS(16.9个月)长于未接受辅助治疗的患者(4.6个月,8.7个月)(P<0.01)。[结论]疾病分期、手术方式和是否接受辅助治疗是影响胰腺癌患者预后的重要因素。
[Purpose] To investigate potential factors related to survival in patients with pancreatic cancer.[Methods] One hundred and twenty-three cases with pancreatic cancer were analyzed retrospectively to study factors related to survival by Log-Rank and Cox multiplicity analysis.[Results] The median time to progress （TTP） and overall survival （OS） was 7.0 months and 11.6 months respectively.Stratified analysis showed that the median TTP（13 months） and median OS（24.3 months） of patients with stage Ⅰ and Ⅱ were longer than that of patients with stage Ⅲ and Ⅳ,and similarly,those with stage Ⅲ （median TTP：5 months;median OS：10.1 months） were better than those with stage Ⅳ （median TTP：2.5 months;median OS：3.9 months）（P0.001）.The median TTP and OS in patients who received radical surgery were 11.3 months and 15.6 months respectively,were longer than those of non-excisional patients（including both shunt operation and paracentesis）（P0.01）,but between palliative shunt operation and diagnostic paracentesis only,there were no statistical significance（median TTP：5 months vs.4.8 months;median OS：10.1 months vs.7.8 months）.The median TTP and OS in patients with post-operation adjuvant therapy were longer than those in patients without （median TTP：12.8 months vs.4.6 months;median OS：16.9 months vs.8.7 months）（P0.01）.[Conclusion] Cancer stage,surgical modality and adjuvant therapy are important prognostic factors of pancreatic cancer.
出处
《中国肿瘤》
CAS
2011年第6期462-465,共4页
China Cancer
关键词
胰腺癌
预后
生存期
pancreatic cancer
prognosis
survival
