摘要
目的:评价尿激酶不同给药途径的溶栓效果及安全性。方法:将新鲜兔血栓注入新西兰白兔的一侧颈内动脉(1CA),15min后经不同的途径给予尿激酶(UK)治疗。结果:治疗开始后2h内动脉途径组(10000u·kg^(-1))血管再通率100%;静脉途径组(10000和20000u·kg^(-1))分别为33%和100%。动脉途径组平均再通时间(53.6±13.1)min,静脉途径组(20000u·kg^(-1))为(89.1±14.8)min。结论:动脉途径的溶栓效果及安全性优于静脉途径。
Aim: To evaluate the thrombolytic efficacy and safety of different urokinase (UK)therapy routes by doppler ultrasonics. Methods: A fresh blood clot was injected into one internal carotid artery of a New Zealand white rabbit. 15 min later, UK was administrated by different routes, and ICA blood flow was detected by doppler ultrasonics. Results: ICA blood flow was reestablished within 2 h in all rabbits treated with a regional intra-arterial UK infusion, 2 out of 6(10 000u·kg-1)and 10 out of 10(20 000u·kg-1)in the groups treated with intravenous infusion, respectively. The mean reestablishing time of the flow was(53. 6±13.1)min and (89. 1± 14.8)min in the groups treated with a regional intra-arterial UK infusion and in the group treated with intravenous infusion (20 000u·kg-1), respectively. Conclusion: The thrombolytic efficacy and safety of UK administrated in regional intra-arterial UK infusion were superior to that administrated in intravenous infusion.
出处
《中国临床神经科学》
1999年第4期207-211,共5页
Chinese Journal of Clinical Neurosciences
关键词
兔
尿激酶
脑梗塞
给药
溶栓疗法
rabbit urokinase cerebral embolism doppler ultrasonics thrombolytic therapy
