摘要
目的探讨乳酸脱氢酶（LDH）及其同工酶对鉴别诊断胸腔积液中良、恶性疾病及监测其病程预后的临床价值。方法将207例伴有胸水的肺癌、结核性胸膜炎及肺炎、心功能不全、心力衰竭患者分为三组，LDH采用酶法检测，其同工酶则以醋纤琼脂糖电泳法进行酶谱分析。分别检测患者胸水和血清LDH及其同工酶。结果结核性胸膜炎患者胸水LDH增加显著，为1294±212．9U／L，与自身血清相比有显著差异（P＜0．001），同工酶以LDH4、5增加明显，肺癌病人的胸水LDH为1021±363．8U／L，与自身血清相比也具显著性差异（P＜0．001），同工酶以LDH5为主，而肺炎、心功能不全和心衰者胸水LDH为161±54．3U／L，与其血清相比无统计学意义，同工酶酶谱也无临床意义。结论血清和胸水LDH及其同工酶测定对心衰，肺部感染、结核性胸膜炎具有重要的鉴别诊断及监测疾病病程和预后的价值。
Objective To study the clinical significance of LDH and its isoenzyme in pleural effusion in the differential diagnosis and prognosis of diseases. methods Two hundred and seven patients with pleural effusion resulted from lung carcinoma, tuberculous pleurisy, pneumonia, cardiac insufficiency and cardiac failure were divided into 3 groups and LDH in the pleural effusion were determined with HITACHI 7170 automatic enzyme analyzer, LDH's isoenzyme with acetic acid agarose gel electrophoresis. Results LDH in pleural effusion of tuberculous pleurisy was 1294±212. 9U/L,markedly increased in comparison with that in self - serum(P < 0. 001); notable inerease was found in isoenzyme. LDH4 and LDH5. LDH in pleural effusion of patients with lung carcinoma was 1021± 363. 8U/L, also significantly different from self - serum(P < 0. 001 ) and the isoenzyme was mainly LDH5; while LDH in plenral effusion from patients with pneumonia, cardiac insufficiency and cardiac failure were 161 ± 64 . 3U/L, without significant difference from self - serum, as well as isoenzyme. Conclusion Determination of LDH and its isoenzyme in serum and plearal effusion is of significant value in differential diagnosis and monitoring the course of disease and prognosis in patients with cardiac failure,pulmonary infection and tuberculous pleurisy.
出处
《江西医学检验》
1999年第4期212-213,208,共3页
Jiangxi Journal of Medical Laboratory Sciences
关键词
乳酶脱氢酶
LDH同工酶
胸腔积液
Lactate dehydrogenase Isoenzyme Serum Pleural effusion
