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结肠癌患者血清VEGF、CEA和CRP联合检测的临床意义 被引量:10

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摘要 目的:研究血清癌胚抗原(CEA)、血管内皮生长因子(VEGF)和C反应蛋白(CRP)联合检测在结肠癌诊断治疗中的临床价值。方法:收集40例结肠癌患者(结肠癌组),30例良性病变患者(良性病变组)和30例正常对照者(正常对照组)的静脉血标本,应用ELISA法检测血清VEGF含量,用放射免疫法分析CEA含量,采用胶乳增强免疫比浊法检测CRP含量并用Beckman Coulter Lx20全自动生化分析仪进行测定。结果:结肠癌组患者VEGF、CEA和CRP含量均高于正常对照组,差异有统计学意义(P<0.001)。良性病变组VEGF水平高于正常对照组(P<0.05);CRP也明显高于正常对照组,差异有统计学意义(P<0.001)。结肠癌组VEGF和CEA水平高于良性病变组(P<0.05)。血清VEGF、CEA和CRP联合检测的敏感性、特异性和诊断阳性率分别为85.6%、66.8%和93.2%。结论:血清VEGF、CEA和CRP联合检测可提高结肠癌患者诊断的敏感性和诊断符合率,为结肠癌患者术前临床诊治和术后辅助治疗提供帮助。
出处 《实用医学杂志》 CAS 北大核心 2011年第13期2393-2394,共2页 The Journal of Practical Medicine
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