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6氯-8-烃-基-9芳-基嘌呤类化合物的合成 被引量：2

Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives
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摘要 以4,6二-氯-5氨-基嘧啶为原料,经N-烃基化反应、缩合反应和氯化反应,合成了一系列未见文献报道的6氯--8烃-基-9芳-基嘌呤衍生物,所有化合物均通过1H NMR、MS和元素分析确定其结构。研究结果表明,N-烃基化反应时,芳胺使用盐酸作催化剂,芳基脂肪胺用有机碱三乙胺作催化剂,缩合反应时,多聚磷酸(PPA)用量过多会影响传质效果,影响反应的收率。讨论了微波反应方式对氯化反应的影响。 Using 4,6-dichlorin-5-amino-pyrimidine as a starting material,a serials of 6-chlorin-8-alkyl-9-aryl-purine derivatives have been designed and synthesized via N-alkylation,condensation and chloridization.All synthesized compounds were confirmed by elemental analysis,MS and 1H NMR techniques.The effects of catalyst on N-alkylation,the amounts of polyphosphoric acid（PPA） on condensation,the microwave heating process on chloridization were investigated.
作者 陆鸿飞 张亮泽 武鼎铭 穆维宁 周君涛
机构地区 江苏科技大学材料科学与工程学院
出处 《应用化学》 CAS CSCD 北大核心 2011年第7期747-752,共6页 Chinese Journal of Applied Chemistry
基金 江苏省自然科学基金(BK2009721) 江苏科技大学博士人才(2008CL181)资助项目
关键词 嘌呤衍生物 N-烃基化 缩合 氯化 合成 purine derivatives N-alkylation condensation chloridization synthesis
分类号 O631 [理学—高分子化学]
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参考文献14

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同被引文献25

  • 1王要令,徐军,陈宜俍,宗旭.酸性离子液体研究新进展[J].山东化工,2007,36(1):9-12. 被引量：6
  • 2陆鸿飞,陆明,吕春绪,贺鹰,张康康.2-氨基-6-卤代嘌呤的合成[J].精细化工,2006,23(4):386-388. 被引量：4
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应用化学
2011年 第7期

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