摘要
目的 探讨先天性胆道闭锁（ＣＢＡ）肝脏毛细胆管超微结构与临床预后的关系。方法 用Ｐｈｉｌｉｐｓ ＣＭ１０ 透射电镜观察肝内毛细胆管超微结构，比较肝组织电镜切片中发育良好与发育不良的毛细胆管数目，并与临床预后作比较。结果 ２７ 例ＣＢＡ 患儿中，肝内毛细胆管发育良好为主１３例，其中１２ 例术后生存，生存率为９２．３１ ％ ；毛细胆管发育不良为主的１４ 例中，仅有４ 例生存，生存率为２８ ．５７ ％ ，两组生存率有显著性差异（ Ｐ＜ ０．０５） 。结论 肝内毛细胆管发育良好为主的ＣＢＡ 患儿术后生存率较发育不良为主的高。
Objective To investigate the relationship between the ultrastructure of intrahepatic biliary canaliculi and the prognosis of biliary atresia. Methods Transmission electromicroscopy(Philips CM10) was performed on the liver biopsies from 27 patients who were operated on congenital biliary atresia. The number of well developed biliary canaliculi was correlated with the prognosis. Results The survival rates of 13 patients with well developed intrahepatic biliary canaliculi and 14 patients with poorly developed intra hepatic biliary canaliculi were 92.3?% (12/13) and 28.6?% (4/14) respectively. The difference between the two groups was statistically significant( P < 0.05 ). Conclusion Intra hepatic biliary canaliculi ultrastructure could be used as one of the prognostic factors in biliary atresia.
出处
《中华小儿外科杂志》
CSCD
1999年第5期294-295,共2页
Chinese Journal of Pediatric Surgery
