摘要
目的探讨S100A4、CB蛋白在乳腺癌中的表达情况及二者与乳腺浸润性导管癌的浸润、转移的关系。方法应用免疫组织化学SP法分别检测20例正常乳腺组织、20例乳腺良性病变组织和40例乳腺浸润性导管癌中S100A4、CB蛋白的表达。结果 20例正常乳腺组织中S100A4及CB蛋白的阳性表达率分别为25.0%(5/20)及15.0%(3/20),20例乳腺良性病变组织中S100A4蛋白阳性表达率30.0%(6/20)及35.0%(7/20),40例乳腺浸润性导管癌组织中S100A4及CB蛋白阳性表达率为67.5%(27/40)及72.5%(29/40),在乳腺浸润性导管癌组织中,S100A4蛋白的表达与患者年龄、肿瘤的组织学分级无关(P>0.05),而与淋巴结转移密切相关(P<0.05),CB蛋白的表达与患者年龄无关(P>0.05),而与淋巴结转移、肿瘤的组织学分级密切相关(P<0.05),S100A4蛋白与CB蛋白的表达呈正相关(P<0.05)。结论 S100A4及CB蛋白在乳腺浸润性导管癌中均高表达,且与乳腺的浸润和淋巴结转移密切相关。
Objective To investigate the expressions of S100A4 and CB proteins in the breast invasive ductal carcinoma and their corelationship with invasion and metastasis.Methods The expressions of S100A4 and CB proteins were detected by the immunohistochemical SP method in 20 samples of breast normal tissues,in 20 samples of benign breast lesions and in 40 samples of the breast invasive ductal carcinoma.Results The positive expression rates of S100A4 and CB protein in 20 samples of normal breast tissues were 25.0%（5/20） and 5.0%（3/20）,the positive expression rates of S100A4 and CB protein in 20 samples of breast benign lesions were 30.0%（6/20） and 35.0%（7/20）,the positive expression rates of S100A4 and CB proteins in 40 samples of the breast invasive ductal carcinoma were 67.5%（27/40） and 72.5%（29/40）.In breast invasive ductal carcinoma,the expression rate of S100A4 protein had relationship with lymph node metastasis（P0.05）and did not have a relationship with the age and the tumor histological grade（P0.05）,and the expression rate of CB protein had relationship with lymph node metastasis and the tumor histological grade（P0.05）and did not have a relationship with the age（P0.05）.Conclusions S100A4 and CB protein were high expression in breast invasive ductal carcinoma,and the expressions of S100A4 and CB protein were positively correlated with the invasion and lymph node metastasis of breast invasive ductal carcinoma.
出处
《医药论坛杂志》
2011年第8期11-13,共3页
Journal of Medical Forum
基金
河南省科技攻关项目(项目号:072102310061)
