摘要
目的观察腹腔复苏对失血性休克家兔血乳酸(BL)浓度、酸碱平衡状态,探讨其在失血性休克救治中的作用。方法 21只雄性家兔随机分为三组,腹腔复苏组(A组)、常规静脉复苏组(B组)、正常对照组(C组)。A、B组于10 min内使MAP降至40 mm Hg,维持60 min后,在20 min内静脉回输放出的血液和两倍于放血量的复方乳酸钠进行液体复苏,并于血液和液体复苏的同时,A组腹腔内注射120 ml临床用透析液,而B、C组腹腔注入等量生理盐水对照。观察休克前后与复苏后的MAP,测定动脉血pH、HCO-3、BE、BL。复苏后180 min,取门静脉血测定BL浓度,然后静脉注射空气处死家兔。结果复苏后30、60、90 min,A组MAP高于B组(P<0.01)。复苏后60、180min时A组静脉血和复苏后180 min门静脉血BL值明显低于B组(P<0.05),pH、HCO-3、BE分别高于B组(P<0.05或P<0.01)。且A组在复苏后180 min与C组相应值相近,同时也接近休克前水平。结论腹腔复苏对失血性休克的早期救治具有一定的实用价值。
Objective To investigate the effects of peritoneal resuscitation on blood lactate, acid base balance in rabbits with hemorrhagic shock. Methods Twenty-one male rabbits were rando mly divided into 3 groups： peritoneal resuscitation（group A）, conventional resuscitation（group B）, and no hemorrhagic shock（group C）. The hemorrhagic shock was Obtained by exsanguinate with MAP to 40 nml Hg for 60 minutes followed by twice exsanguinate volumes of ringer＇s lactate. At the same time, group A received 120 ml dialysate and group B and C received the same volume of saline. The MAP, pH, HCO3^- , BE, and blood lactate（BL）were measured before shock, 60 min after shock, 60 and 180 min after resuscitation. BL in portal vein was also determined 180 rain after resuscitation. Results Compared with group B, MAP in group A was better maintained （P〈0. 01）, blood lactate was significantly decreased （P 〈 0.05）, and acid base imbalance was improved （P〈 0.05） . Conclusions Peritoneal resuscitation is effective for hemorrhagic shock in the early stage.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2011年第6期587-589,共3页
Journal of Clinical Anesthesiology
关键词
失血性休克
腹腔复苏
乳酸
酸碱平衡
Hemorrhagic Shock
Peritoneal resuscitation
Lactate
Acid base balance
