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胃癌中LIMK1的表达及其病理意义 被引量：6

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摘要 目的探讨LIMK1在胃癌中的表达及其临床病理意义。方法应用组织芯片与免疫组织化学SP法检测81例胃癌、26例不典型增生及34例正常组织中LIMK1的表达水平,分析其与胃癌临床分期、有无淋巴结转移等临床病理特征的关系。结果 LIMK1在正常组织、不典型增生与胃癌中表达呈递增趋势(P<0.05);弥漫型胃癌阳性率明显高于肠型胃癌(P<0.05)。肿瘤直径≤3.0 cm的胃癌中LIMK1的表达明显低于>3.0 cm的表达(P<0.05);淋巴结转移组表达明显高于未转移组(P<0.05)。TNM分期Ⅲ、Ⅳ期表达明显高于Ⅰ、Ⅱ期(P<0.05);LIMK1表达与患者性别差异无显著性(P>0.05)。结论 LIMK1与胃癌的分化程度、肿瘤大小、淋巴结转移、临床分期密切相关,可能是胃癌侵袭转移重要的生物标记物。
作者 吴勇军 唐仪 李筝 张漾 赵毅 伍镇江 苏琦
机构地区 南华大学附属湘潭医院病理科 南华大学肿瘤研究所
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2011年第6期658-660,共3页 Chinese Journal of Clinical and Experimental Pathology
基金 湖南省科技厅科技计划(2008SK3010) 湘潭市科技局科技计划(SF20081003)
关键词 胃肿瘤 组织芯片 LIMK1 免疫组织化学
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献6

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二级参考文献43

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共引文献138

同被引文献48

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  • 3苏坚,贺修胜,容映晖,廖前进,苏琦,李艳兰,周健国.DADS诱导人结肠癌细胞双向电泳图谱的差异分析[J].中国药理学通报,2006,22(5):583-587. 被引量：15
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引证文献6

二级引证文献17

临床与实验病理学杂志
2011年 第6期

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