摘要
目的:回顾分析输卵管开窗术联合甲氨喋呤治疗异位妊娠的临床效果,评价腹腔镜下输卵管开窗术联合术中病灶局部注射甲氨喋呤(MTX)对提高异位妊娠后生育力的价值。方法:收集2002年1月～2007年12月在南昌大学第二附属医院住院诊断为异位妊娠的240例患者,按照手术方式及术后MTX的使用方案将其分为A组、B组、C组、D组。随访4组患者治愈后的生育力情况,随访时间为治疗后3年。结果:D组与A组、B组、C组术后1年内、2年内、3年内的宫内妊娠率、不孕率及异位妊娠再发率对照,经χ2检验,差异有统计学意义(P<0.01)。D组术后第1次宫内妊娠时间与A组、B组、C组对照,差异性显著(P<0.01)。结论:腹腔镜下输卵管开窗术联合术中病灶注射MTX治疗异位妊娠在治疗的同时可最大程度的保留患侧输卵管的功能,相对开腹行输卵管开窗术或术后予肌注MTX的治疗方法,对患者生育力的影响小。
Objective：To analyze the clinical efficacy of oviduct fenestration combined with methotrexate in treatment of ectopic pregnancy retrospectively,evaluate the value to improve fertility.Methods：240 cases diagnosed with ectopic pregnancy in the hospital from January 2002 to December 2007 in the hospital were collected,then they were divided into A group,B group,C group and D group according to operation methods and postoperative application schemes of methotrexate.The fertile conditions of the four groups were followed up for 3 years after treatment.Results：There was significant difference in intrauterine pregnancy rate,infertility rate and occurrence rate of ectopic pregnancy within one,two and three years after treatment between D group and A group,B group,C group（P0.01）.There was significant difference in the first intrauterine pregnancy time after treatment between D group and A group,B group,C group（P0.01）.Conclusion：Oviduct fenestration combined with methotrexate injection can reserve the function of fallopian tube of diseased side to greatest extent in treatment of ectopic pregnancy,it has less impact on fertility of the cases with ectopic pregnancy compared with simple oviduct fenestration or simple intramuscular injection of methotrexate after operation.
出处
《中国妇幼保健》
CAS
北大核心
2011年第18期2843-2844,共2页
Maternal and Child Health Care of China
基金
江西省教育厅科技基金项目〔GJJ10348〕
关键词
异位妊娠
输卵管开窗术
甲氨喋呤
Ectopic pregnancy
Oviduct fenestration
Methotrexate
