期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

蛋白磷酸酶2A对微管的调控作用研究进展 被引量：2

The Progress on Regulation of Microtubule by PP2A
原文传递
导出
摘要 微管是细胞骨架的主要成分之一,几乎存在于所有真核生物细胞之中,参与细胞众多生理功能。PP2A是真核生物体内存在最广泛的蛋白磷酸酶之一,可以调控大部分细胞生命活动,其中,包括微管所介导的许多生命活动。该文从以下方面介绍了PP2A在微管功能行使中的重要作用,包括PP2A参与微管蛋白翻译后修饰、调控分子马达和微管相关蛋白的活性、维持细胞周期中微管的动态平衡以及PP2A异常与微管类疾病的相关性。 Microtubule is one of the important components of cytoskeleton, which exists in almost all eu karyotic cells and participates in a variety of essential cellular functions. PP2A is a major serine/threonine protein phosphatase in eukaryotic cells which is involved in many regulation pathways including microtubule-related pro- cess. The current paper presents the important role of PP2A on microtubule with focus on the post-translated modi- fications of tubulin, regulation of activity of molecular motors, dynamic balance of microtubule in cytokinesis and microtubule diseases.
作者 梁婧 徐立红
机构地区 浙江大学医学院生物化学与遗传学系
出处 《中国细胞生物学学报》 CAS CSCD 2011年第6期705-710,共6页 Chinese Journal of Cell Biology
基金 国家自然科学基金(No.30771827 No.20777067) 国家科技重大专项(No.2008ZX07421-001)资助项目~~
关键词 蛋白磷酸酶2A 微管 微管蛋白 分子马达 微管相关蛋白 PP2A microtubule tubulin molecular motor MAP
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献43

  • 1Kong M, Ditsworth D, Lindsten T, Thompson CB. Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell 2009; 36(1): 51-60.
  • 2Gurland G, Gundersen GG. Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells. Proc Natl Acad Sci USA 1993; 90(19): 8827-31.
  • 3Merrick SE, Trojanowski JQ, Lee VM. Selective destruction of stable microtubules and axons by inhibitors of protein serine/ threonine phosphatases in cultured human neurons. J Neurosci 1997; 17(15): 5726-37.
  • 4Tar K, Birukova AA, Csortos C, Bako E, Garcia JG, Verin AD. Phosphatase 2A is involved in endothelial cell mierotubule re- modeling and barrier regulation. J Cell Biochem 2004; 92(3): 534-46.
  • 5Tar K, Csortos C, Czikora I, Olah G, Ma SF, Wadgaonkar R, et al. Role of protein phosphatase 2A in the regulation of endothelial cell cytoskeleton structure. J Cell Biochem 2006; 98(4): 931-53.
  • 6Sasse R, Gull K. Tubulin post-translational modifications and the construction of microtubular organelles in Trypanosoma brucei. J Ceil Sci 1988; 90 (Pt 4): 577-89.
  • 7Piperno G, LeDizet M, Chang XJ. Microtubules containing acetylated alpha-tubulin in mammalian cells in culture. J Cell Biol 1987; 104(2): 289-302.
  • 8Fath T, Eidenmuller J, Brandt R. Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. J Neurosci 2002; 22(22): 9733-741.
  • 9Kreitzer G, Liao G, Gundersen GG. Detyrosination of tubulin regulates the interaction of intermediate filaments with microtu- bules in vivo via a kinesin-dependent mechanism. Mol Biol Cell 1999; 10(4): 1105-18.
  • 10Contin MA, Purro SA, Bisig CG, Barra HS, Arce CA. Inhibitors of protein phosphatase 1 and 2A decrease the level of tubulin carboxypeptidase activity associated with microtubules. Eur J Biochem 2003; 270(24): 4921-9.

同被引文献38

  • 1陈慧莉,李建华,王树庆.线粒体跨膜电位和细胞凋亡相关性的研究[J].医学综述,2007,13(14):1041-1043. 被引量：35
  • 2王卫东,陈正堂.Bcl-2/Bax比率与细胞“命运”[J].中国肿瘤生物治疗杂志,2007,14(4):393-396. 被引量：165
  • 3Bombrun A,Gerber P,Casi G,Terradillos O,Antonsson B,Halazy S,2003.3,6-dibromocarbazole piperazine derivatives of 2-propanolas first inhibitors of cytochrome c release via Bax channelmodulation.Journal of Medicinal Chemistry,46(21):4365–4368.
  • 4Borner C,2003.The Bcl-2 protein family:sensors and checkpointsfor life-or-death decisions.Molecular Immunology,39(11):615–647.
  • 5Carrel JE,Eisner T,1974.Cantharidin:potent feeding deterrent toinsects.Science,183(4126):755–757.
  • 6Chandna S,Suman S,Chandna M,Pandey A,Singh V,Kumar A,Dwarakanath BS,Seth RK,2013.Radioresistant Sf9 insect cellsundergo an atypical form of Bax-dependent apoptosis at veryhigh doses ofγ-radiation.International Journal of RadiationBiology,89(12):1017–1027.
  • 7Chen XE,Liu JY,Zhang YL,2014.Cantharidin impedes the activityof protein serine/threonine phosphatase in Plutella xylostella.Molecular Bio Systems,10(2):240–250.
  • 8Deng LP,Dong J,Cai H,Wang W,2013.Cantharidin as anantitumor agent:a retrospective review.Current MedicinalChemistry,20(2):159–166.
  • 9Ganesan V,Walsh T,Chang KT,Colombini M,2012.The dynamicsof Bax channel formation:influence of ionic strength.Biophysical Journal,103(3):483–491.
  • 10Gómez-Crisóstomo NP,López-Marure R,Zapata E,Zazueta C,Martínez-Abundis E,2013.Bax induces cytochrome c release bymultiple mechanisms in mitochondria from MCF7 cells.Journalof Bioenergetics and Biomembranes,45(5):441–448.

引证文献2

二级引证文献3

中国细胞生物学学报
2011年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部