摘要
天然免疫系统是多细胞动物抵御细菌感染的第一道防线。Akirin是新近发现于果蝇中的天然免疫系统新成员,它在果蝇免疫缺陷(Imd)通路中发挥重要作用。Akirin同源基因广泛存在于从低等多细胞生物到高等脊椎动物中,进化上高度保守。已有的研究表明:Akirin在果蝇Imd通路和脊椎动物TLR通路下游,与NF-κB家族转录因子形成复合物,参与调控免疫相关靶基因的转录,是天然免疫调控机制中不可或缺的转录因子,其过表达或缺失直接影响动物对细菌的防御能力。近年来,Akirin在相关信号通路中的功能研究取得重大进展。该文对Akirin的结构、参与天然免疫的分子调控机制以及基因进化等方面进行综述。
The innate immune system is the first defense against the microorganisms in all metazoans. Aki-rin, as a new nuclear factor which discovered in the innate immune response of Drosophila melanogaster, plays a critical role in the immune deficiency. （Imd） pathway. Akirin proto-orthologue gene exists in a wide range of meta-zoans from Choanoflagellates, Drosophila to mammals and its sequences are highly conserved. In the Imd pathway of Drosophila and the Toll pathway of vertebrates, Akirin combining with the transcription factor NF-kB can modu- late the transcription of target genes. Besides, Akirin＇s overexpression and knockout influence animals＇ defense ability against bacteria. Recently, some progress has been made in the immune-related signaling pathway of Akirin. This article will summarize its structure, function, regulatory mechanisms and evolution.
出处
《中国细胞生物学学报》
CAS
CSCD
2011年第6期699-704,共6页
Chinese Journal of Cell Biology
基金
国家自然科学基金(No.30070586)
山东省高等学校科技计划(No.J10LC21)资助项目~~
