摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者是否存在免疫功能的异常。方法回顾性研究187名确诊OSAHS患者及20名体检健康对照组资料,观察指标包括整晚睡眠监测、体液免疫、细胞免疫。结果 OSAHS与正常健康对照组比较,体液免疫中C3明显升高,IgM下降,细胞免疫中NK细胞所占T淋巴细胞的百分率明显下降(P<0.01);相关性分析示C3与呼吸暂停低通气指数(AHI)正相关、与经皮最低血氧饱和度(LSpO2)负相关;IgM与LSpO2弱正相关;NK细胞与AHI弱负相关;其他免疫功能指标在统计学上无显著相关性。结论 OSAHS患者存在免疫功能改变,可能存在免疫功能下降。
Objective To explore the potential changes in the immune function of patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods We carried out a retrospective cross-sectional study of 187 patients with established OSAHS and 20 healthy subjects （control）. For all the patients, the medical history was carefully examined, and overnight sleep monitoring was carried out with detection of the humoral and cellular immunity. Results We found a significant increase in the levels of C3 and a decrease in both the IgM level and NK cell percentage in OSAHS patients as compared to the control group （P〈0.01）. Correlation analysis indicated that C3 was positive correlated to AHI but inversely to the lowest pulse oxygen saturation （LSpO2）; IgM showed a mild positively correlation to LSpO2, and NK cells had a mild inverse correlation to AHI. The other immunological indices were not found to undergo noticeable changes or show correlations in OSAHS. Conclusions Immune function changes occur in patients with OSAHS, characterized primarily by deteriorations in the humoral and cellular immunity.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2011年第6期1003-1005,共3页
Journal of Southern Medical University
基金
国家自然科学基金(30471720)~~
