期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

硫氧还蛋白-1:一个新的疾病氧化应激损伤标志物 被引量：2

原文传递
导出
摘要 新近研究提出,氧化应激损伤是糖尿病及其并发症,以及心血管疾病的重要发病机制之一,干预氧化应激可能成为心血管疾病治疗的新靶点。硫氧还蛋白-1(Trx-1)作为维持细胞内蛋白质还原状态的主要的二硫键还原酶,在对抗细胞的氧化应激,维持细胞正常生理活性中起着重要的作用。同时有学者提出,血清中Trx-1的水平可以作为判断机体氧化应激损伤及疾病程度的一个生物标志物。本文对Trx-1的结构、功能、调控及与疾病的相关性做一综述。
作者 王云 常志文
机构地区 首都医科大学附属北京同仁医院干部医疗科
出处 《心脏杂志》 CAS 2011年第3期392-394,399,共4页 Chinese Heart Journal
关键词 硫氧还蛋白-1 氧化应激 糖尿病 冠状动脉疾病
分类号 Q554.9 [生物学—生物化学]
  • 相关文献

参考文献12

  • 1Beck,BC.Novel approaches to treat oxidative stress and cardiovascular diseases[J].Trans Am Clin Climatol Assoc,2007,118:209-214.
  • 2Lillig CH,Holmgren A.Thioredoxin and related molecules-from biology to health and disease[J].Antioxid Redox Signal,2007,9(1):25-47.
  • 3Billiet L,Furman C,Larigauderie G,et al.Enhanced VDUP-1 gene expression by PPARgamma agonist induces apoptosis I human macrophage[J].J Cell Physiol,2008,214(1):183-191.
  • 4Patwaril P,Higgins LJ,Chutkow WA,et al.The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange[J].J Biol Chem,2006,281(31):21884-21891.
  • 5Wahlgren CM, Pekkari K.Elevated thioredoxin after angioplasty in peripheral arterial disease[J].Eur J Vasc Endovasc Surg,2005,29(3):281-186.
  • 6Tanito M,Nakamura H,Kwon YW,et al.Enhanced oxidative stress and impaired thioredoxin expression in spontaneously hypertensive rats[J].Antioxid Redox Signal,2004,6(1):89-97.
  • 7陶凌,臧益民,刘慧荣,高峰,马新亮.硝基化修饰导致硫氧还蛋白不可逆的丧失了对心脏的保护作用(英文)[J].心脏杂志,2005,17(4):307-312. 被引量：4
  • 8张航向,臧益民,李树壮,高峰,马新亮.抗硝基化治疗对硫氧还蛋白活性及缺血/再灌注后心肌细胞凋亡的影响(英文)[J].心脏杂志,2008,20(3):253-258. 被引量：1
  • 9Ouedraogo R,Wu X,Xu SQ,et al.Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells evidence for involvement of a cAMP signaling pathway[J].Diabetes,2006,55(6):1840-1846.
  • 10Hamada Y,Miyata S,Nii-Kono T,et al.Overexpression of thioredoxin 1 in transgenic mice suppresses development of diabetic nephropathy[J].Nephrol Dial Transplant,2007,22(6):1547-1557.

二级参考文献33

  • 1Gill C, Mestrll R, Samali A. Losing heart: The role of apoptosis in heart disease-a novel therapeutic target? [ J ]. FASEB J, 2002,16 : 135 - 146.
  • 2Webster KA, Bishopric NH. Apoptosis inhibitors for heart disease[ J ]. Circulation, 2003, 108:2954 - 2956.
  • 3Ma XL, Kurnar S, Gao F, et al. Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion [ J ]. Circulation, 1999, 99:1685 -1691.
  • 4Yamawaki H, Haendeler J, Berk BC. Thioredoxin: A key regulator of cardiovascular homeostasis [ J ]. Circ Res, 2003, 93 : 1029 -1033.
  • 5Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1 [ J].EMBOJ, 1998, 17:2596-2606.
  • 6Liu Y, Min W. Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptesis in a redox activity-independent manner[J]. Circ Res, 2002, 90:1259-1266.
  • 7Kuhn DM, Aretha CW, Geddes TJ. Peroxynitrite inactivation of tyrosine hydroxylase: mediation by sulfhydryl oxidation, not tyrosine nitration[J]. J Neurosd, 1999, 19:10289- 10294.
  • 8Guo W, Adachi T, Matsui R, et al. Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in anglotensin II-infused rat kidney [ J ]. Am J Physiol Heart Circ Physiol, 2003,285 : H1396 - H1403.
  • 9Zou MH, Shi C, Cohen RA. High glucose via peroxynitrite causes tyrosine nitration and inactivation of pmstaoyelin synthase that is associated with thromboxane/prostaglandin H ( 2 ) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells[ J]. Diabetes, 2002, 51:198-203.
  • 10Hattori I, Takagi Y, Nakamura H, et al. Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice[J]. Antioxid Redox Signal, 2004, 6:81 -87.

共引文献3

同被引文献39

  • 1徐运.氧化应激与脑缺血再灌注损伤[J].中国卒中杂志,2008,3(3):195-197. 被引量：16
  • 2范义 ,滕妍 ,张启周 ,胡卫东 ,娄明武 .人硫氧还蛋白对脑缺血作用的CT灌注与SOD相关性的实验研究[J].北华大学学报（自然科学版）,2005,6(4):306-310. 被引量：6
  • 3Chade AR, Lerman A, Lerman LO. Kidney in early atherosclerosis [ J ]. Hypertension, 2005,45 ( 6 ) : 1042 - 1049.
  • 4Honda HM, Korge P, Weiss JN. Mitochondria and ischemia/reperfu- sion injury [ J ]. Ann NY Acad Sci,2005,1047 (6) :248 - 258.
  • 5Stephens JW, Khanolkar MP, Bain SC. The biological relevance and measurement of plasma markers of oxidative stress in diabetes and car- diovascular disease [ J ]. Atherosclerosis, 2009,202 ( 2 ) : 321 - 329.
  • 6Cherubini A, Ruggiero C, Polidori MC, et al. Potential markers of oxi- dative stress in stroke [ J ]. Free Radic Biol Med,2005,39 (7) : 841 - 852.
  • 7Stocker R, Keaney JF Jr. Role of oxidative modification in atheroscle- rosis[J]. Phsiol Rev,2004,84(4) :1381 - 1478.
  • 8Fang R, Zhang N, Wang C,et al. Relations between plasma ox -LDL and carotid plaque among Chinese Han ethnic group [ J]. Neurol Res,2011,33 (5) :460 -466.
  • 9Holvoet P, Kritchevsky SB, Tracy RP, et al. The meatabolic syn- drome, circulating oxidized LDL and risk of myocardia infarction in well-functioning elderly people in the health, aging, and body compo- sition cohort [ J ]. Diabetes,2004,53 ( 4 ) : 1068 - 1071.
  • 10Holvoet P, Lee DH, Steffes M, et al. Association between circulating oxidized low-density lipoprotein and incidence of the metabolic syn- drome[ J ]. JAMA,2008,299 (19) :2287 - 2293.

引证文献2

二级引证文献19

心脏杂志
2011年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部