摘要
目的:探讨医院感染肺炎克雷伯菌(KPN)的临床分布及耐药性,为临床医师合理用药提供实验室依据。方法:对187株肺炎克雷伯菌的标本来源和临床科室分布进行调查,细菌培养与鉴定严格按照《全国临床检验操作规程》,采用常规方法进行;药敏试验采用K-B法,结果依据CLSI最新折点进行评价。结果:医院感染肺炎克雷伯菌对碳青霉烯类抗生素亚胺培南、美罗培南敏感率为100%,但对其他常用抗菌药物均产生了不同程度的耐药性,对氨苄西林耐药率最高,达到95.2%(178/187)。结论:各级医院应加大细菌耐药性监测力度,遏制细菌耐药性迅速增长的不良趋势。
Objeetive..To approach the clinical distribution and antimicrobial resistance of Klebsiella pneumoniae （KPN） causing nosocomial infections and provide experimental evidence for clinically reasonable use of antibiotics. Method：Retrospective review was performed to analyze the specimen source and the clinical distribution for 187 isolates of KPN. Referring to National Guide to Clinical Laboratory Procedures,bacteria cultivation and identification were carried out by the routine methods. Antibiotic susceptibility test was performed by K-B, and drug-resistance results were assessed according to the latest version of CLSI breakpoints. Result： 100% of KPN were sensitive to carbapenems such as imipenem and meropenem. KPN were resistant to the other commonly used antibiotics in varying degree. The drug-resistance rate of ampicillin was the highest, reaching 95.2 % （178/187）. Conclusion.. Hospitals should strengthen monitoring of antimicrobial resistance to restrain the increasing tendency of it.
出处
《临床血液学杂志（输血与检验）》
CAS
2011年第3期342-343,共2页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
肺炎克雷伯菌
医院感染
耐药性
监测
klebsiella pneumoniae
nosocomial infections
antimicrobial infections
monitoring
