摘要
目的 通过对30例孤独谱系障碍学龄前儿童的病例对照研究,对孤独谱系障碍的母亲孕期危险因素进行探讨.方法 采用自拟的＂健康因素调查表＂对患儿及正常儿童进行回顾性调查,分析孤独谱系障碍的母亲孕期危险因素.结果 母亲孕期情绪不愉快（β=0.754,χ2=8.510,P=0.004）、病毒性感冒（β=1.583,χ2=9.683,P=0.001）、风疹（β=1.689,χ2=5.261,P=0.024）、轻度（β=1.122,χ2=5.232,P=0.022）和重度（β=2.076,χ2=6.215,P=0.013）新生儿窒息经单因素、多因素Logistic回归分析差异有统计学意义,说明这些因素可能是导致孤独谱系障碍发生的母亲孕期危险因素.结论 减少母亲孕期危险因素的发生,对孤独谱系障碍的防治有重要意义.
Objective To discuss the mother＇ s pregnancy risk factors for autistic spectrum disorder by control study of 30 preschool children with autistic spectrum disorder. Methods A retrospective study was made on children patients and healthy children with self- designed health factors questionnaire to analyze the mothers＇ pregnancy risk factors for autistic spectrum disorder. Results Univariate and multivariate logistic regression analysis of unpleasant emotions during pregnancy （β = 0. 754, X^2 = 8.510, P = 0.004 ）, viral influenza（β= 1. 583, X^2 = 9. 683, P = 0.001 ）, rubella（β = 1. 689, X^2 = 5. 261, P = 0. 024）, mild （β = 1. 555, X^2 = 5. 232, P = 0. 022） and severe （β =2.076,X^2 = 6. 215, P = 0. 013 ） neonatal asphyxiahave showed that the differences were statistically significant, which suggested that these factors might be mother＇ s pregnancy risk factors leading to autistic spectrum disorder. Conclusion Reducing mother＇ s pregnancy risk factors is important in preventing and curing autistic spectrum disorder.
出处
《中国妇幼健康研究》
2011年第3期271-272,290,共3页
Chinese Journal of Woman and Child Health Research
基金
深圳市福田区公益基金资助项目（FTWS012）
关键词
孤独谱系障碍
孕期
危险因素
学龄前儿童
autistic spectrum disorder
pregnancy
risk factors
preschool children
