摘要
目的探讨老年原发性肝细胞癌患者行肝切除术后的治疗效果。方法自1989年1月至2008年12月,共有1 225例原发性肝细胞癌患者于我院行肝切除术,挑选其中年龄≥60岁、有完整临床资料及随访结果的112例患者进行回顾性分析,并随机抽取同期年龄<60岁的135例患者作对照。结果老年组患者术后并发症发生率为8.9%(10/112),对照组患者术后并发症发生率为11.1%(15/135),两者相比差异无统计学意义(P>0.05)。老年组患者术后1、3、5年无瘤生存率为66.2%,48.7%,43.2%,对照组分别为63.2%,41.2%,37.3%,两组相比差异无统计学意义(P=0.372)。而老年组1、3、5年生存率分别为82.2%,55.4%,43.5%,而对照组分别为70.8%,37.1%,30.9%。老年组患者生存率明显好于对照组,差别具有统计学意义(P=0.012)。结论肝切除术是治疗老年原发性肝癌一种积极有效的治疗方法。对于没有术前合并症或能够有效控制术前合并症的老年原发性肝癌患者而言,肝切除术是安全的,可做为治疗的首选方案。
Objective To evaluate the curative effect of hepatectomy for elderly patients with hepatocelluar carcinoma（HCC）.Methods From January 1989 to December 2008,1 225 patients with HCC underwent hepatectomy in our hospital.The clinical data and treatment outcomes of 112 elderly patients suffered from HCC（elderly group,≥60 years of age） and 135 younger patients（control group,60 years of age） who selected randomly from the 1 225 patients were retrospectively analyzed.Results The rate of postoperative complications was 8.9%（10/112） in the elderly group,and 11.1%（15/135） in the control group.There was no significant difference between two groups.The tumor-free survival rates after hepatectomy at 1,3 and 5 years were 66.2%,48.7% and 43.2% in the elderly group respectively,and 63.2%,41.2% and 37.3% in the control group,respectively.The was no significant difference between two groups.The overall survival rates after hepatectomy at 1,3 and 5 year were 82.2%,55.4% and 43.5% in the elderly group respectively,and 70.8%,37.1% and 30.9% in the control group,respectively.The postoperative long-term survival rate in the elderly group was significantly better than that in the control group（P=0.012）.Conclusion Hepatic resection is effective for elderly patients with HCC.For the elderly patients without preoperative comorbidities or with controlled comorbidities,hepatic resection is a safe and effective treatment.
出处
《肝胆胰外科杂志》
CAS
2011年第3期212-214,218,共4页
Journal of Hepatopancreatobiliary Surgery
关键词
老年人
原发性肝细胞癌
肝切除术
预后
the elderly
hepatocelluar carcinoma
hepatectomy
prognosis
