摘要
目的探讨吸入布地奈德混悬液与硫酸特布他林、异丙托溴铵雾化液联合雾化吸入对慢性阻塞性肺疾病急性加重期(acuteexacerbations of chronic obstructive pulmonary disease,AECOPD)的疗效。方法将82例AECOPD患者随机分为两组,治疗组42例,对照组40例,两组均予吸氧、抗感染、静脉茶碱类及对症等治疗。在此基础上治疗组给予吸入布地奈德、硫酸特布他林和异丙托溴铵混悬液雾化吸入,对照组单用硫酸特布他林雾化液雾化吸入,对两组患者用药7 d后的呼吸困难、血气分析及第1秒用力呼气容积占预计值百分比(FEV1%)变化情况进行对照分析。同时比较两组的平均住院日。结果治疗组与对照组相比,治疗组在呼吸困难、PaO2、PaCO2、FEV1%、平均住院日均较对照组改善明显,两组差异具有显著性(P<0.01)。结论采用布地奈德、硫酸特布他林和异丙托溴铵混悬液雾化吸入的多靶点抗炎治疗对AECOPD能够迅速缓解病情,改善肺功能,是治疗AECOPD的有效选择。
Objective To eva luate the therapy of inha ling nebu lized budesonide suspension comb ined w ith terbuta line and ipratropium sulphate fo rtreatment of chronic obstructive pulmonary disease atacu te exacerbations phase（AECOPD）.Methods eighity-two patients w ith AECOPD w ere random ly div ided into observ ed g roup（42 cases） and control group（40 cases）.Both g roups were adm inistered the therapy of oxygen inhalation,anti-infection and intravenous am inophylline.On the basis of routine the rapy,the patients in the observed group were given nebu lized budeson ide suspension inhalation and terbuta line and ipratropium sulphate,and the control group were administered on ly terbutaline sulphate inhalation;then the clinical manifestation,despanish blood gasanalysis and FEV1% at base line and 7 days after treatment were determined.Results The despanish PaO2,PaCO2 and FEV1% were sign ifican tly different in the treatment group before and after the therapy（P〈0.01）.Conclusions The therapy of inhaling nebulized budesonide suspension combing with terbutaline and ipratropium sulphate aerosol may effective ly relieve the symptoms of AECOPD.Its the choice the rapy for AECOPD.
出处
《临床肺科杂志》
2011年第7期1018-1020,共3页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
布地奈德
硫酸特布他林
异丙托溴铵
chronic obstructive lung diseases
nebulized budesonide suspension
terbutaline sulphate
ipratropium sulphate
