摘要
目的:探讨奥氮平治疗精神分裂症的疗效及不良反应。方法:将213例精神分裂症患者随机分为研究组(奥氮平)和对照组(氯丙嗪),共治疗8周。治疗前后应用简明精神病评定量表(BPRS)、住院患者观察量表(NOSIE)和副反应量表(TESS)分别评定疗效及不良反应。结果:在治疗第2周末、第8周末,研究组的BPRS各因子分及总分均低于对照组,差异具有显著性意义(P<0.05),研究组的NOSIE的社会功能、个人整洁、总积极因素因子分及病情总估计分均高于对照组,抑郁、迟缓及总消极因素因子分均低于对照组,差异也具有显著意义(P<0.05)。奥氮平的不良反应明显少于氯丙嗪。结论:奥氮平可有效改善精神分裂症患者的精神病症状和社会功能。
Objective：To study efficacy and adverse effects of Olanzapine in treatment of schizophrenia.Methods：A total of 213 patients with schizophrenia were randomly divided into study group with Olanzapine and control group with Chlorpromazine for treatment of 8 weeks.They were assessed and analysed conlrastively using Brief Psychiatric Rating Scale（BPRS）,Nurses Observation Scale（NOSIE） and Treatment Emergent Side Effect Scale（TESS）.Results：In the second weedend and eighth weekend of treatment,the total and factors scores of BPRS in study group were all significantly improved than those before treatment（P0.05）,the factor scores of social function,personal cleanliness,total positive factors and the total scores of NOSIE in study group were all significantly higher than those in control group（P0.05）,but the factor scores of depression,retardation factor and total negative factors of NOSIE in study group were significantly lower than those in control group（P0.05）.Conclusion：Olanzapine is effective to improve psychiatric symptoms and social functions of patients with schizophrenia.
出处
《中国民康医学》
2011年第10期1196-1197,1277,共3页
Medical Journal of Chinese People’s Health
关键词
奥氮平
氯丙嗪
精神分裂症
Olanzapine
Chlorpromazine
Schizophrenia
