摘要
目的：研究中国汉族人群血管紧张素转换酶（ＡＣＥ）基因插入／缺失（Ｉ／Ｄ）多态性与冠心病的关系。方法：应用聚合酶链反应（ＰＣＲ）检测４０例冠心病和５０例配伍对照组的血管紧张素转换酶（ＡＣＥ）基因型，同时测血压、血脂、体重指数等指标。结果：冠心病组与对照组ＡＣＥ基因型分布无显著性差异，ＤＤ型对ＤＩ型和Ⅱ型优势比ＯＲ＝１．５２，９５％可信区间为０．５５～４．２２，Ｐ＞０．０５。结论：ＡＣＥ基因Ｉ／Ｄ多态性与中国汉族人群冠心病的发生无关，也不是有价值的遗传标志。
Purpose: In order to investigate the relationship between insertion/deletion(I/D)polymorphism of angiotensin-convert- ing enzyme(ACE)gene and coronary heart diseade(CHD)in Chinese Han population.Methods:The genotype of ACE was examined by polymerase chain reaction (PCR)in 40 patients with CHD and 50 matched subjects.Results:The results showed that the distribution of ACE genotype was not significantly different between the cases and controls.The odd ratio for CHD with DD genotype compared with Ⅱ and DI genotype was 1.25(95% percent confidence limit,0.55-4.22,P>0.05).Conclusion: The results indicated that I/D polymorphism of ACE gene may not be involved in the pathogenesis of CHD,and not be a useful genetic marker for CHD in Chinese Han people.
出处
《天津医药》
CAS
1999年第12期707-710,共4页
Tianjin Medical Journal
关键词
冠心病
ACE
基因多态性
coronary disease peptidyl-dipeptidase A genes restriction fragment length polymorphism
