摘要
目的探讨高血压病患者左心室重构的不同阶段血清脂联素（APN）水平与左心室儿何构型的关系．方法对133例高血压病患者进行超声心动图检查，依据左心室质量指数、左心窒相对室壁厚度将患者分为左心室正常构型组、左心室向心性重构组、左心室向心性肥厚组和左心室离心性肥厚组。30例健康体检者为对照组。ELISA法测定血清APN水平。结果对照组、左心室正常构型组、左心室向心性重构组之间血清APN水平比较差异无显著性（P〉0．05）。与对照组比较，左心室向心性肥厚组和左心室离心性肥厚组高血压病患者的血清APN水平显著降低（P〈0．01），日左心室离心性肥厚组APN水平下降的更明显（P〈0．01）。左心室肥厚组患者的血清APN水平与左心室质量指数呈显著的负相关（P〈0．05）。结论在规范化治疗的高血压病患者，血清APN水平仍能很好的反映左心室肥厚的程度。
Objective To investigate the relationship between serum adiponeetin （ APN ） level and left venlricular geomelry in patients with essential hypertension, blethods Echoeardiography was performed on 133 patients with essential hypertension. According to left ventricular mass index（ LVMI ） and relative wall thickness （ RWT ）, patients were divided into normal geometry group （ n = 37 ）, concentric remodeling group（ n=32 ）, concentric hypertrophy group （ n = 34 ）and eccentric hypertrophy group（ n = 30 ）. 30 healthy subjects were used as control. Serum APN levels were measured by enzymelinked immunosorbent assay. Results Serum APN levels did not differ significantly among the control group, the normal geometry group, and the concentric remodeling group （ P〉 0.05 ）. As compared with those in the control group, serum APN levels were markedly lower in the concentric hypertrophy group and the eccentric hypertrophy group （ P〈 0.01 ）, especially in the latter group （ P〈 0.01 ）. APN levels were negatively related with LVMI （ P 〈 0.05 ） in those with ventricular hypertrophy. Conclusions Serum APN levels can still reflect the degree of left ventricular hypertrophy in hypertensive patients receiving standard therapies.
出处
《国际医药卫生导报》
2011年第11期1299-1302,共4页
International Medicine and Health Guidance News
关键词
高血压病
脂联素
左心室肥厚
Essential hypertension
Adiponectin
Left ventricular hypertrophy
