摘要
目的评价亚洲骨质疏松自我评价工具(OSTA)和我国妇女骨质疏松筛选工具(OSTC)与四川地区围绝经期和绝经后汉族妇女骨密度的关系,比较两种工具对骨质疏松症的筛检能力,探讨其临床应用价值。方法 2010年7—10月筛选获得356名45岁以上妇女的双能X线骨密度仪腰椎、股骨颈和全髋骨密度数据,利用体重和年龄分别计算OSTA指数与OSTC指数,并进行比较。结果 OSTA指数与OSTC指数和各部位骨密度值均呈正相关(r=0.458～0.593和r=0.440～0.599,P<0.001),两种筛选指数之间呈正相关(r=0.956,P<0.001)。按两级危险程度分类界值进行判定,OSTA和OSTC的灵敏度分别为78.2%、93.5%,特异度为67.2%、43.0%,受试者工作特征曲线下面积为0.792、0.798,Kappa系数为0.452、0.357。结论 OSTA与OSTC应用于四川地区围绝经期和绝经后妇女骨质疏松症的筛查效果均不理想,临床应用价值受限。
Objective To evaluate the relationship between osteoporosis self-assessment tool for asians（OSTA）,osteoporosis self-assessment tool for Asians（OSTC） and bone mineral density in Sichuan perimenopausal and postmenopausal women of Han nationality,and discuss the value of their clinical application through comparison of the screening ability of the two tools in predicting osteoporosis and low bone mass.Methods With the data of bone mineral density at lumbar spine,femoral neck and total proximal femur measured by DXA of 356 women aged 45 years old and above,OSTA and OSTC risk indexes of each subject were calculated based on their weight and age,and were then compared.Results The bone mineral density of above-mentioned locations were positively correlated with OSTA and OSTC indexes（r=0.458-0.593 and r=0.440-0.599,P0.001）,and these two indexes were also correlated positively（r=0.956,P0.001）.According to the two risk levels by these cutoffs,OSTA and OSTC indexes could diagnose osteoporosis with the sensitivity of 78.2% and 93.5%,the specificity of 67.2% and 43%,the area under ROC curve of 0.792 and 0.798,and the Kappa value of 0.452 and 0.357,respectively.Conclusion Both OSTA and OSTC were not ideal tools for screening osteoporosis in perimenopausal and postmenopausal women in Sichuan province.
出处
《华西医学》
CAS
2011年第5期656-659,共4页
West China Medical Journal
关键词
骨密度
骨质疏松症
骨质疏松自我评价工具
筛检效果
Bone mineral density
Osteoporosis
Osteoporosis self-assessment tool
Screening effect
