摘要
目的了解上海市二、三级医院结肠与直肠手术围术期抗菌药物预防用药(PAP)的情况。方法上海市医院感染质量控制中心2010年的4月与10月对市监测网二甲以上医院进行围术期抗菌药物预防用药的调查。结果监测网医院中35所(16所三级和19所二级医院)上报结直肠手术围术期抗菌药物预防静脉用药资料共673例,其中结肠手术482例,直肠手术191例;应用的抗菌药物共11类43个品种,以头孢菌素类应用率最高,占40.3%(二代头孢菌素24.3%,三代头孢菌素8.9%),其次是硝基咪唑类,占37.0%;围术期抗菌药物预防用药单用、二联和三联分别占19.3%、69.2%、11.5%;联合用药中以头孢菌素类+硝基咪唑类最为常见,占46.2%;围术期抗菌药物预防用药的平均使用时间为(5.8±2.9)d。结论上海市结直肠手术的围术期抗菌药物预防用药存在单用、三联用药比例较高、配伍不合理、用药时间过长等问题,应引起重视。
OBJECTIVE To evaluate the situation of perioperative antibiotic prophylaxis（PAP） in colorectal surgery.METHODS Hospitals administered by the Shanghai Nosocomial Infection Control Center（SNICC） were required to investigate the application of PAP in their hospitals in Apr and Oct 2010.The data of the surveillance was reported to SNICC through network.RESULTS The data of 35 hospitals involved the information of PAP in colorectal surgery.Overall,673 cases of surgery were enrolled in the study,including 482 colon surgeries and 191 rectal surgeries.Eleven categories and 43 kinds of antibiotics were applied,the most frequently used category was cephalosporin,accounting for 40.3% of all the utilization,followed by the nitromidazole（37.0%）.The rates of single use,combination of two antibiotics,and combination of three antibiotics were 19.3%,69.2% and 11.5%,respectively.Cephalosporin plus nitromidazole was the most frequently used regimen of PAP in colorectal sugery（46.2%）.The mean time of PAP was 5.8±2.9d（0-21 d）.CONCLUSION Single antibiotic application,irrational drug combinations and long-term utilization of PAP still exist in the colorectal surgeries in Shanghai,and the high proportion of the combination of three antibiotics,which is worthy to pay attention to.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第12期2570-2572,共3页
Chinese Journal of Nosocomiology
