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艾普拉唑三联疗法治疗消化性溃疡的疗效观察 被引量:4

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摘要 目的研究艾普拉唑三联疗法治疗消化性溃疡的疗效及安全性。方法选取消化性溃疡患者80例,随机分治疗组和对照组各40例,分别给予以艾普拉唑或以奥美拉唑为基础的三联疗法治疗,治疗时间均为4周。结果治疗结束时,两组临床症状缓解有效率间的差异无统计学意义(P>0.05),但是治疗组症状完全缓解天数少于对照组(P<0.05)。两组溃疡愈合率和幽门螺杆菌转阴率差异无统计学意义(P>0.05)。结论 艾普拉唑三联疗法治疗消化性溃疡起效迅速,疗效稳定,是安全、有效的治疗方案。
作者 杨东胜
出处 《齐齐哈尔医学院学报》 2011年第8期1266-1267,共2页 Journal of Qiqihar Medical University
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  • 1陈灏珠.实用内科学[M].第10版.北京:人民卫生出版社,2005:2273-2274.
  • 2Mégraud FH.pyloriantibiotic resistance:prevalence,importance,and advances in testing[J].Gut,2004,53(9):1374-84.
  • 3李桃,李秀梅,蒋松.雷贝拉唑四联疗法治疗消化性溃疡合并幽门螺杆菌感染的疗效观察[J].中国实用医药,2010,5(4):143-144. 被引量:30
  • 4Kwon D,Chae JB,Park CW,et,al.Effects of IY-81149,a newly developed protonpumpinhibitor,on gastric acid secretion in vitro and in vivo[J].Arzneimittelforschung,2001,51(3):204-213.
  • 5Ho KY,Kuan A,Zano F,et al.Randomized,parallel,double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers[J].J Gastroenterol,2009,44(7):697-707.
  • 6Periclou AP,Goldwater R,Lee SM,et al.A comparative pharmacodynamic study of IY-81149 versus omeprazole in patients with gastroesophageal reflux disease[J].Clin Pharmacol Ther,2000,68(3):304-11.

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  • 1Sachs G. Proton pump inhibitors and acid-related diseases [ J ]. Pharmacotherapy, 1997,17 ( 1 ) :22-37.
  • 2Mullin JM, Gabello M, Murray LJ, et al. Proton pump inhibitors : actions and reactions [ J ]. Drug Discovery Today, 2009,14 ( 13/14 ) : 648-660.
  • 3Sachs G, Shin JM, Howdeu CW. Review article:the clinical pharmacology of proton pump inhibitors [ J ]. Aliment Pharmacol Ther, 2006,23 ( Suppl 2) :2-8.
  • 4Shi S, Klotz U. Proton pump inhibitors:an update of their clinical use and pharmacokinetics [ J ]. Eur J Clin Pharmacol, 2008,64 (10) :935-951.
  • 5Kim E J, Lee RK, Lee SM, et al. General pharmacology of IY- 81149, a new proton pump inhibitor [ J ]. Arzneimittelforschung, 2001,51 (1) :51-59.
  • 6Kwon D,Chae JB,Park CW,et al. Effect of IY-81149,a new developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo [ J ]. Arzneimittelforschung, 2001,51 ( 3 ) : 204-213.
  • 7Kil BJ,Kim IW,Shin CY,et al. Comparison of IY81149 with omeprazole in rat reflux oesophagitis [ J ]. J Auton Pharmacol, 2000,20 (5/6) :291-296.
  • 8Perielou AP, Goldwater R, Lee SM,et al. A comparative pharmacodynamic study of IY-81149 versus omeprazole in patients with gastroesophageal reflux disease [ J ]. Clin Pharmaeol Ther, 2000,68 (3) :304-311.
  • 9Li Y, Zhang W, Guo D, et al. Pharmaeokinetics of the new proton pump inhibitor ilaprazole in Chinese healthy subjects in relation to CYP3A5 and CYP2C19 genotypes[J]. Clin Chim Acta,2008,391 (1/2) :60-67.
  • 10Song M, Gao X, Hang TJ, et al. Pharmacokinetic properties of Lansoprazole( 30-mg emetic-coated capsules )and its metabolites: a single-dose, open-label study in healthy Chinese male subjects [ J]. Current Therapeutic Research ,2009,70(3 ) :228-239.

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