摘要
目的:评价双环醇片治疗氯丙嗪、氯氮平所致肝损害的临床疗效和安全性。方法:将115例使用氯丙嗪、氯氮平后所致肝损害的患者随机分为两组,治疗组58例,接受每日口服双环醇片75 mg治疗,对照组57例,采用保肝药物水飞蓟宾胶囊治疗,观察连续用药4周后的临床疗效和安全性。结果:在肝功能与综合疗效方面,两组均得到改善,但治疗组更为明显,差异有显著性(P<0.05,P<0.01);未发现与双环醇片有关的不良事件。结论:双环醇片治疗由氯丙嗪、氯氮平所致肝损害有效且安全。
Objective：To analyze the efficacy and reliability of bicyclol on the treatment of hepatic Lesion induced by Chlorpromazine or Clozapine.Methods：115 patients with drug hepatitis were divided into two groups and received bicyclol orally 75mg daily or Silybin Capsules 210 mg daily for 4 weeks.The efficacy and reliability were observed.Results： Compared with pre-treatment,the liver function and synthetic curative effect were all improved in two groups.Bicyclol 75mg daily group is better（P〈0.05,P〈0.01）.There were no obvious adverse events which were probably dealed with bicyclol by investigator’s estimation in the study.Conclusions： Bicyclol 75 mg tablets daily are effective and reliable on treating hepatic Lesion induced by Chlorpromazine or Clozapine.
出处
《中国民康医学》
2011年第11期1314-1316,共3页
Medical Journal of Chinese People’s Health
关键词
双环醇
氯丙嗪
氯氮平
肝损害
Bicyclol； Chlorpromazine； Clozapine； Hepatic Lesion；
