期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

p16蛋白及Ki-67在所谓肺硬化性血管瘤细胞中的表达及意义 被引量：1

暂未订购
导出
摘要 目的探讨p16蛋白及Ki-67在所谓肺硬化性血管瘤(PSH)组织两种主要细胞中的表达及意义。方法采用SP免疫组化法检测30例PSH及10例肺炎性假瘤标本中p16蛋白及Ki-67的表达情况。结果 PSH组织中p16蛋白阳性表达率为3.33%(1/30),阳性细胞为多角形核表达,表面立方细胞均为阴性表达。5例PSH的多角形细胞Ki-67散在阳性表达。肺炎性假瘤中增生的肺泡Ⅱ型上皮细胞p16蛋白及Ki-67的表达与PSH中立方细胞的表达情况相同。结论 PSH中的表面立方上皮细胞分化相对成熟,p16蛋白阳性率及Ki-67增殖指数高于表面立方上皮,提示多角形细胞多处于"未分化状态"。
作者 齐凤杰 赵树鹏
机构地区 辽宁医学院 辽宁医学院附属第一医院
出处 《山东医药》 CAS 北大核心 2011年第20期67-69,共3页 Shandong Medical Journal
基金 辽宁医学院博士科研启动基金资助项目(2009715)
关键词 肺肿瘤 P16 KI-67 免疫组织化学
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1齐凤杰,张秀伟,张永兴,戴顺东,王恩华.所谓肺硬化性血管瘤组织中两种主要细胞的雄激素受体、磷酸甘油酸酯激酶基因多态性分析[J].中华病理学杂志,2006,35(5):267-271. 被引量：18
  • 2齐凤杰,张秀伟,张永兴,王恩华.p53蛋白表达和基因突变在所谓肺硬化性血管瘤组织中的意义[J].中国肺癌杂志,2006,9(2):147-151. 被引量：9
  • 3Xing C,Wang QF,Li B,et al.Methylation and expression analysisof tumor suppressor genes p15 and p16 in benzene poisoning. Chemico Biological Interactions . 2010
  • 4Nam EJ,Kim JW,Hong JWet al.Expression of the p16and Ki-67in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection. European Journal of Gynaecological Oncology . 2008
  • 5Miyagawa-Hayashino A,Tazelaar H D,Langel D J,et al.Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. Archives of Pathology and Laboratory Medicine . 2003
  • 6Yano M,Yamakawa Y,Kiriyama M,et al.Sclerosing hemangioma with metastases to multiple nodal stations. The Annals of Thoracic Surgery . 2002
  • 7Dacic S,Sasatomi E,Swalsky PA,et al.Loss of heterozygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a similar molecular pathogenesis. Archives of Pathology and Laboratory Medicine . 2004
  • 8Nakatani Y,Inayama Y,Kamijo S,et al.Sclerosing lung hemangioma. The American Journal of Surgical Pathology . 1999
  • 9Wang E,Lin D,Wang Y,et al.Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. Human Pathology . 2004

二级参考文献30

  • 1Yano M, Yamakawa Y, Kiriyama M, et al. Selerosing hemangioma with metastases to multiple nodal stations. Ann Thorac Surg,2002,73(3) : 981-983.
  • 2Chiba W, Sawai S, Yasuda Y, et al. Positive expression of c-myc and p53 products in two cases of pulmonary sclerosing hemangioma. Nihon Kyobu Shikkan Gakkai Zasshi, 1995,33 (12) : 1348-1354.
  • 3Miller LD, Smeds J, George J, et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.Proc Natl Acad Sci U S A,2005,102 (49) : 17882.
  • 4Devouassoux-Shisheboran M, Hayashi T, Linnoila RI, et al. A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. Am J Surg Pathol,2000,24(7) : 906-916.
  • 5Chan AC, Chan JK. Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1) : a new clue to its histogenesis. Am J Surg Pathol, 2000, 24 (11) : 1531-1536.
  • 6Wang E, Lin D, Wang Y, et al. Immunohistochemical and ultrastructural markers suggest different origins for cuboidal and polygonal cells in pulmonary sclerosing hemangioma. Hum Pathol,2004,35(4) : 503-508.
  • 7Niho S, Suzuki K, Yokose T, et al. Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. Am J Pathol,1998,152(4) :1065-1069.
  • 8Dacic S, Sasatomi E, Swalsky PA, et al. Loss of heterozygosity patterns of sclerosing hemangioma of the lung and bronchioloalveolar carcinoma indicate a similar molecular pathogenesis. Arch Pathol Lab Med,2004,128(8) : 880-884.
  • 9Miyagawa-Hayashino A, Tazelaar HD, Langel DJ, et al. Pulmonary sclerosing hemangioma with lymph node metastases: report of 4 cases. Arch Pathol Lab Med,2003,127(3) : 321-325.
  • 10Shabnam MS, Srinivasan R, Wall A, et al. Expression of p53 protein and the apoptotic regulatory molecules Bcl-2, Bcl-XL, and Bax in locally advanced squamous cell carcinoma of the lung. Lung Cancer,2004,45(2) : 181-188.

共引文献21

同被引文献9

引证文献1

二级引证文献3

山东医药
2011年 第20期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部