摘要
目的研究血清IL-18水平在高血压左心室肥厚中的临床意义。方法选择单纯原发性高血压病患者、高血压左心室肥厚患者以及体检健康者各40例,应用ELISA法检测血清IL-18水平;同时检测相关生化指标及高血压危险因素。结果高血压左心室肥厚患者血清IL-18水平高于单纯原发性高血压组和对照组(P<0.05),单纯原发性高血压患者血清IL-18水平高于对照组(P<0.05)。对于不同等级的高血压各组中,IL-18水平随着血压的上升而升高(P<0.05)。IL-18与LVM I呈正相关,与HDL呈负相关。结论 IL-18水平可作为高血压合并左心室肥厚病情及预后的一项参考指标。
Objective To investigate the expression and the clinical significance of serum interleukin-18（IL-18） in patients with hypertension and left ventricular hypertrophy（LVH）.Methods The level of IL-18 was measured by enzyme-linked immunosorbent assay in 40 patients with essential hypertension,40 patients with LVH and 40 normal controls.To analyze relative biochemical indicators and risk factors of hypertension.Results The level of serum IL-18 in LVH group was significantly higher than that of essential hypertension group and control group（P0.05）.The level of serum IL-18 in essential hypertension group was significantly higher than that of control group（P0.05）.For different degrees of hypertension in each group,IL-18 levels increased with rising blood pressure（P0.05）.IL-18 was positive correlation with LVMI,and negative correlation with HDL.Conclosions IL-18 may be involved in the occurrence and development of hypertension,and then affect the process of LVH and cardiac function.IL-18 level in serum is closely associated with LVH,which is useful to estimate the severity and prognosis in LVH patients.
出处
《山东医药》
CAS
北大核心
2011年第20期36-38,共3页
Shandong Medical Journal
关键词
高血压
左心室肥厚
白细胞介素18
hypertension
left ventricular hypertrophy
interleukin-18
