摘要
目的:研究单剂量po阿莫西林咀嚼片和普通片后,阿莫西林在血浆中的药物动力学与相对生物利用度.方法:采用高效液相色谱法测定10名健康男性受试者草剂量po750mg阿莫西林咀嚼片和普通片后,血浆中阿莫西林浓度变化情况;计算药物动力学参数与相对生物利用度.结果:咀嚼片与普通片的药-时曲线均符合一房室模型.主要药物动力学参数分别为t_(max)(70.92±9.38)和(78.01±18.97)min;C_(max)(10.09±2.62)和(9.86±3.14)μg/ml;AUC(2136.53±481.83)和(2182.83±524.12)(min·μg)/ml.咀嚼片的相对生物利用度为97.88%.结论:两种片剂药物动力学参数间无显著性差异(P>0.05);两药具有生物等效性.
AIM: To study the pharmacokinetics and relative bioavailability of amoxicillin tablets. METHODS: Amoxicillin was determined after a single oral dose (750 mg) of two kinds of amoxicillin tablets were given to 10 healthy male volunteers in an open randomized cross-over test. The amoxicillin concentration in serum was assayed by high performance liquid chromatography method. RESULTS: It was found that the serum concentration time curves of 2 preparations were fitted to an one compartment model. The t_(max) of masticatory tablet and normal tablet were (70.92±9.38) and (78. 01 ±18. 97)mini;c(max) were (10. 09±2.62) and (9.86±3. 14)μg/ml; AUC were (2 136.53 ± 481.83) and (2 182. 83±24. 12) (min μg)/ml, respectively. The relative bioavalibility of masticatory tablet is 97.88%. CONCLUSION: The result of statistical analysis shows that there is no significant difference in each pharmacokinetics parameter between 2 preparations. The result suggests that the bioavalibility of 2 preparations is similar.
出处
《中国临床药学杂志》
CAS
1999年第4期222-224,共3页
Chinese Journal of Clinical Pharmacy
关键词
阿莫西林
药物动力学
生物利用度
<keywords>amoxicillin
pharmacokinetics
bioavaliability
