摘要
目的 分析男性无精症患者染色体异常发生的情况。方法 对５５ 例无精症患者及５５ 例对照组进行常规外周血淋巴细胞培养、染色体制备及分析。结果 ５５ 例无精症患者中，１８ 例染色体结构或数目异常，占３３％ ，其中性染色体异常为主。５５ 例对照组中１ 例染色体结构异常。结论 染色体异常是导致无精症的重要原因之一，细胞及分子遗传学检查对决定无精症患者的病因和治疗是很有必要的。
Objective To determine whether male aspermatogenesis is related to chromosomal abnormalities. Methods Lymphocytes were cultured from peripheral blood of 55 aspermatogenesis patients and 55 normal control subjects. The chromosomes were prepared and analyzed routinely in both the patients and the normal subjects. Results Abnormalities in chromosomal structure and number, particularly in sex chromosomes, were found in 18(33%) patients with aspermatogenesis, while only in 1 case of the control group. Conclusion Abnormal chromosome is an important factor that could result in aspermatogenesis. It suggests that cytogenetics analysis is necessary for determination of pathogenesis and guidance of clinical therapy to aspermatogenesis.
出处
《广东医学》
CAS
CSCD
1999年第9期667-668,共2页
Guangdong Medical Journal
